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- W2009454294 abstract "The in vitro dissolution kinetics of three different suppository formulations of indomethacin was studied using two different apparatuses, namely, a flow-through cell (Dissotest ®) and a dialysis rotating cell (Pharmatest ®). A comparison between both apparatuses was carried out and two types of dissolutions became apparent depending on whether the excipient used in the formulation was either hydrophilic or lipophilic. The distinction between dissolution profiles was more evident using the flow-through cell. From the in vivo curves parameters furnished by the manufacturers, in vitro/in vivo correlations were performed. A linear relationship was established between the in vitro results obtained and the in vivo percentages absorbed that were calculated according to the Wagner-Nelson method. Simulated blood concentration-time curves were generated from the in vitro released data and the pharmacokinetic parameters obtained. A good superimposition of the experimental plasma concentrations and the simulated curves was obtained with the flow-through cell and the hydrophilic suppository dosage form whereas the simulation with the lipophilic suppository gave imperfect results irrespective of the apparatus used." @default.
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- W2009454294 date "1992-09-01" @default.
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- W2009454294 title "Study on the release of indomethacin from suppositories: in vitro-in vivo correlation" @default.
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- W2009454294 doi "https://doi.org/10.1016/0378-5173(92)90140-w" @default.
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