Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009455581> ?p ?o ?g. }
- W2009455581 endingPage "71" @default.
- W2009455581 startingPage "59" @default.
- W2009455581 abstract "Hedgehog (HH) and Decapentaplegic (DPP) direct anteroposterior patterning in the developing Drosophila wing by functioning as short- and long-range morphogens, respectively. Here, we show that the activity of DPP is graded and is directly regulated by a novel HH-dependent mechanism. DPP activity was monitored by visualizing the activated form of Mothers against dpp (MAD), a cytoplasmic transducer of DPP signaling. We found that activated MAD levels are highest near the source of DPP but are unexpectedly low in the cells that express dpp. HH induces dpp in these cells; it also attenuates their response to DPP by downregulating expression of the DPP receptor thick veins (tkv). We suggest that regulation of tkv by HH is a key part of the mechanism that controls the level and distribution of DPP." @default.
- W2009455581 created "2016-06-24" @default.
- W2009455581 creator A5017294704 @default.
- W2009455581 creator A5045293577 @default.
- W2009455581 creator A5046914597 @default.
- W2009455581 creator A5086823047 @default.
- W2009455581 date "2000-01-01" @default.
- W2009455581 modified "2023-10-13" @default.
- W2009455581 title "Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs" @default.
- W2009455581 cites W1529816420 @default.
- W2009455581 cites W157700276 @default.
- W2009455581 cites W1580962701 @default.
- W2009455581 cites W1637612807 @default.
- W2009455581 cites W1659071674 @default.
- W2009455581 cites W1663371441 @default.
- W2009455581 cites W1822814742 @default.
- W2009455581 cites W1871724379 @default.
- W2009455581 cites W1889479151 @default.
- W2009455581 cites W1970344958 @default.
- W2009455581 cites W1971855104 @default.
- W2009455581 cites W1974410953 @default.
- W2009455581 cites W1990059201 @default.
- W2009455581 cites W1992374635 @default.
- W2009455581 cites W1996500821 @default.
- W2009455581 cites W2000646745 @default.
- W2009455581 cites W2003038417 @default.
- W2009455581 cites W2010863761 @default.
- W2009455581 cites W2015877043 @default.
- W2009455581 cites W2016232806 @default.
- W2009455581 cites W2016350172 @default.
- W2009455581 cites W2017826121 @default.
- W2009455581 cites W2021554803 @default.
- W2009455581 cites W2027197247 @default.
- W2009455581 cites W2027440964 @default.
- W2009455581 cites W2028497134 @default.
- W2009455581 cites W2029307548 @default.
- W2009455581 cites W2041892053 @default.
- W2009455581 cites W2041970325 @default.
- W2009455581 cites W2045655335 @default.
- W2009455581 cites W2046804699 @default.
- W2009455581 cites W2048917073 @default.
- W2009455581 cites W2049425193 @default.
- W2009455581 cites W2053838962 @default.
- W2009455581 cites W2057591552 @default.
- W2009455581 cites W2057723597 @default.
- W2009455581 cites W2058016050 @default.
- W2009455581 cites W2070107376 @default.
- W2009455581 cites W2072468208 @default.
- W2009455581 cites W2076324043 @default.
- W2009455581 cites W2078402042 @default.
- W2009455581 cites W2080213723 @default.
- W2009455581 cites W2084024013 @default.
- W2009455581 cites W2086654524 @default.
- W2009455581 cites W2089417576 @default.
- W2009455581 cites W2092386534 @default.
- W2009455581 cites W2094271503 @default.
- W2009455581 cites W2103031848 @default.
- W2009455581 cites W2124955351 @default.
- W2009455581 cites W2128017793 @default.
- W2009455581 cites W2136116871 @default.
- W2009455581 cites W2138222765 @default.
- W2009455581 cites W2140932241 @default.
- W2009455581 cites W2145714841 @default.
- W2009455581 cites W2156086003 @default.
- W2009455581 cites W2159935247 @default.
- W2009455581 cites W2164310262 @default.
- W2009455581 cites W2166841567 @default.
- W2009455581 cites W2177942679 @default.
- W2009455581 cites W2183101699 @default.
- W2009455581 cites W2184390227 @default.
- W2009455581 cites W2185963341 @default.
- W2009455581 cites W2186307273 @default.
- W2009455581 cites W2186847624 @default.
- W2009455581 cites W2188362237 @default.
- W2009455581 cites W321588607 @default.
- W2009455581 doi "https://doi.org/10.1016/s1097-2765(00)80403-7" @default.
- W2009455581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10678169" @default.
- W2009455581 hasPublicationYear "2000" @default.
- W2009455581 type Work @default.
- W2009455581 sameAs 2009455581 @default.
- W2009455581 citedByCount "379" @default.
- W2009455581 countsByYear W20094555812012 @default.
- W2009455581 countsByYear W20094555812013 @default.
- W2009455581 countsByYear W20094555812014 @default.
- W2009455581 countsByYear W20094555812015 @default.
- W2009455581 countsByYear W20094555812016 @default.
- W2009455581 countsByYear W20094555812017 @default.
- W2009455581 countsByYear W20094555812018 @default.
- W2009455581 countsByYear W20094555812019 @default.
- W2009455581 countsByYear W20094555812020 @default.
- W2009455581 countsByYear W20094555812021 @default.
- W2009455581 countsByYear W20094555812022 @default.
- W2009455581 countsByYear W20094555812023 @default.
- W2009455581 crossrefType "journal-article" @default.
- W2009455581 hasAuthorship W2009455581A5017294704 @default.
- W2009455581 hasAuthorship W2009455581A5045293577 @default.
- W2009455581 hasAuthorship W2009455581A5046914597 @default.
- W2009455581 hasAuthorship W2009455581A5086823047 @default.