Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009456013> ?p ?o ?g. }
- W2009456013 endingPage "842" @default.
- W2009456013 startingPage "834" @default.
- W2009456013 abstract "Immuno-electron microscopic and beta-microprobe studies have demonstrated that the internalization of serotonin 5-HT(1A) autoreceptors, after acute treatment with the selective 5-HT(1A) receptor agonist 8-OH-DPAT or with the specific serotonin reuptake inhibitor (SSRI) fluoxetine, is associated with a marked decrease in the in vivo binding of [(18)F]MPPF in the nucleus raphe dorsalis (NRD) of rat. To determine whether this event might be amenable to brain imaging, the present [(18)F]MPPF positron emission tomographic (PET) study was carried out in anesthetized cats given or not a single dose (5 mg/kg, i.v.) or chronically treated with fluoxetine (5 mg/kg, s.c. for 21 days). Compared to control, [(18)F]MPPF binding potential was considerably (and visibly) decreased in the cat NRD after acute fluoxetine treatment, while it remained unchanged in other brain regions. Unexpectedly, after chronic fluoxetine treatment, [(18)F]MPPF binding potential was not affected in any brain region. In parallel immuno-electron microscopic experiments carried out in rat, the density of 5-HT(1A) autoreceptors on the plasma membrane of NRD dendrites was comparable to control after chronic fluoxetine treatment. If the decrease in [(18)F]MPPF binding at the onset of SSRI treatment was detectable by PET imaging, it could potentially serve as a biological index of efficacy." @default.
- W2009456013 created "2016-06-24" @default.
- W2009456013 creator A5006436645 @default.
- W2009456013 creator A5029428115 @default.
- W2009456013 creator A5045245923 @default.
- W2009456013 creator A5061613485 @default.
- W2009456013 creator A5062535346 @default.
- W2009456013 creator A5062730744 @default.
- W2009456013 creator A5070148631 @default.
- W2009456013 date "2006-11-01" @default.
- W2009456013 modified "2023-10-14" @default.
- W2009456013 title "A PET imaging study of 5-HT1A receptors in cat brain after acute and chronic fluoxetine treatment" @default.
- W2009456013 cites W1530059721 @default.
- W2009456013 cites W1860114987 @default.
- W2009456013 cites W1928975456 @default.
- W2009456013 cites W1965776451 @default.
- W2009456013 cites W1970926776 @default.
- W2009456013 cites W1977886627 @default.
- W2009456013 cites W1979561743 @default.
- W2009456013 cites W1983336401 @default.
- W2009456013 cites W1985445017 @default.
- W2009456013 cites W1985993015 @default.
- W2009456013 cites W1989389872 @default.
- W2009456013 cites W1991398637 @default.
- W2009456013 cites W1994702289 @default.
- W2009456013 cites W1996345484 @default.
- W2009456013 cites W1998113639 @default.
- W2009456013 cites W1999399598 @default.
- W2009456013 cites W1999490123 @default.
- W2009456013 cites W2001344969 @default.
- W2009456013 cites W2005467788 @default.
- W2009456013 cites W2007490806 @default.
- W2009456013 cites W2013759477 @default.
- W2009456013 cites W2018085592 @default.
- W2009456013 cites W2020952840 @default.
- W2009456013 cites W2030571181 @default.
- W2009456013 cites W2032994066 @default.
- W2009456013 cites W2034054527 @default.
- W2009456013 cites W2035416510 @default.
- W2009456013 cites W2038018468 @default.
- W2009456013 cites W2038989561 @default.
- W2009456013 cites W2042769585 @default.
- W2009456013 cites W2044779961 @default.
- W2009456013 cites W2045109060 @default.
- W2009456013 cites W2046227869 @default.
- W2009456013 cites W2051531767 @default.
- W2009456013 cites W2058426499 @default.
- W2009456013 cites W2058747520 @default.
- W2009456013 cites W2061494582 @default.
- W2009456013 cites W2064525038 @default.
- W2009456013 cites W2067883239 @default.
- W2009456013 cites W2068965083 @default.
- W2009456013 cites W2070660174 @default.
- W2009456013 cites W2075566185 @default.
- W2009456013 cites W2076112136 @default.
- W2009456013 cites W2080777409 @default.
- W2009456013 cites W2081458788 @default.
- W2009456013 cites W2083213528 @default.
- W2009456013 cites W2103818341 @default.
- W2009456013 cites W2137170135 @default.
- W2009456013 cites W2151018358 @default.
- W2009456013 cites W2158455820 @default.
- W2009456013 cites W2158766525 @default.
- W2009456013 cites W2159612818 @default.
- W2009456013 cites W2161037740 @default.
- W2009456013 cites W2166461470 @default.
- W2009456013 cites W2172038451 @default.
- W2009456013 doi "https://doi.org/10.1016/j.neuroimage.2006.08.012" @default.
- W2009456013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16996750" @default.
- W2009456013 hasPublicationYear "2006" @default.
- W2009456013 type Work @default.
- W2009456013 sameAs 2009456013 @default.
- W2009456013 citedByCount "47" @default.
- W2009456013 countsByYear W20094560132012 @default.
- W2009456013 countsByYear W20094560132013 @default.
- W2009456013 countsByYear W20094560132014 @default.
- W2009456013 countsByYear W20094560132015 @default.
- W2009456013 countsByYear W20094560132017 @default.
- W2009456013 countsByYear W20094560132018 @default.
- W2009456013 countsByYear W20094560132019 @default.
- W2009456013 countsByYear W20094560132021 @default.
- W2009456013 countsByYear W20094560132022 @default.
- W2009456013 crossrefType "journal-article" @default.
- W2009456013 hasAuthorship W2009456013A5006436645 @default.
- W2009456013 hasAuthorship W2009456013A5029428115 @default.
- W2009456013 hasAuthorship W2009456013A5045245923 @default.
- W2009456013 hasAuthorship W2009456013A5061613485 @default.
- W2009456013 hasAuthorship W2009456013A5062535346 @default.
- W2009456013 hasAuthorship W2009456013A5062730744 @default.
- W2009456013 hasAuthorship W2009456013A5070148631 @default.
- W2009456013 hasConcept C126322002 @default.
- W2009456013 hasConcept C134018914 @default.
- W2009456013 hasConcept C170493617 @default.
- W2009456013 hasConcept C185592680 @default.
- W2009456013 hasConcept C2775864247 @default.
- W2009456013 hasConcept C2776134451 @default.
- W2009456013 hasConcept C2777865548 @default.
- W2009456013 hasConcept C2778938600 @default.