FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009457093> ?p ?o ?g. }

• W2009457093 abstract "Chagas disease is caused by an intracellular parasitic protist, Trypanosoma cruzi. As there are no highly effective drugs against this agent that also demonstrate low toxicity, there is an urgent need for development of new drugs to treat Chagas disease. We have previously demonstrated that the parasite inositol 1,4,5-trisphosphate receptor (TcIP3R) is crucial for invasion of the mammalian host cell by T. cruzi. Here, we report that TcIP3R is a short-lived protein and that its expression is significantly suppressed in trypomastigotes. Treatment of trypomastigotes, an infective stage of T. cruzi, with antisense oligonucleotides specific to TcIP3R deceased TcIP3R protein levels and impaired trypomastigote invasion of host cells. Due to the resulting instability and very low expression level of TcIP3R in trypomastigotes indicates that TcIP3R is a promising target for antisense therapy in Chagas disease." @default.
• W2009457093 created "2016-06-24" @default.
• W2009457093 creator A5023625292 @default.
• W2009457093 creator A5035555934 @default.
• W2009457093 creator A5039073991 @default.
• W2009457093 creator A5057828715 @default.
• W2009457093 creator A5075241995 @default.
• W2009457093 creator A5077482664 @default.
• W2009457093 date "2014-02-28" @default.
• W2009457093 modified "2023-09-29" @default.
• W2009457093 title "Antisense Oligonucleotides Targeting Parasite Inositol 1,4,5-Trisphosphate Receptor Inhibits Mammalian Host Cell Invasion by Trypanosoma cruzi" @default.
• W2009457093 cites W1485297825 @default.
• W2009457093 cites W1503077302 @default.
• W2009457093 cites W1980166477 @default.
• W2009457093 cites W1980502182 @default.
• W2009457093 cites W1981568175 @default.
• W2009457093 cites W1984491725 @default.
• W2009457093 cites W2001909617 @default.
• W2009457093 cites W2018743269 @default.
• W2009457093 cites W2024708102 @default.
• W2009457093 cites W2025218591 @default.
• W2009457093 cites W2034081065 @default.
• W2009457093 cites W2034557901 @default.
• W2009457093 cites W2065055751 @default.
• W2009457093 cites W2082071395 @default.
• W2009457093 cites W2094809928 @default.
• W2009457093 cites W2112451562 @default.
• W2009457093 cites W2134958003 @default.
• W2009457093 cites W2147329362 @default.
• W2009457093 cites W2150942343 @default.
• W2009457093 cites W2151825558 @default.
• W2009457093 cites W4210980497 @default.
• W2009457093 doi "https://doi.org/10.1038/srep04231" @default.
• W2009457093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3937783" @default.
• W2009457093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24577136" @default.
• W2009457093 hasPublicationYear "2014" @default.
• W2009457093 type Work @default.
• W2009457093 sameAs 2009457093 @default.
• W2009457093 citedByCount "17" @default.
• W2009457093 countsByYear W20094570932014 @default.
• W2009457093 countsByYear W20094570932015 @default.
• W2009457093 countsByYear W20094570932016 @default.
• W2009457093 countsByYear W20094570932017 @default.
• W2009457093 countsByYear W20094570932019 @default.
• W2009457093 countsByYear W20094570932020 @default.
• W2009457093 countsByYear W20094570932021 @default.
• W2009457093 countsByYear W20094570932022 @default.
• W2009457093 countsByYear W20094570932023 @default.
• W2009457093 crossrefType "journal-article" @default.
• W2009457093 hasAuthorship W2009457093A5023625292 @default.
• W2009457093 hasAuthorship W2009457093A5035555934 @default.
• W2009457093 hasAuthorship W2009457093A5039073991 @default.
• W2009457093 hasAuthorship W2009457093A5057828715 @default.
• W2009457093 hasAuthorship W2009457093A5075241995 @default.
• W2009457093 hasAuthorship W2009457093A5077482664 @default.
• W2009457093 hasBestOaLocation W20094570931 @default.
• W2009457093 hasConcept C104317684 @default.
• W2009457093 hasConcept C112418997 @default.
• W2009457093 hasConcept C129312508 @default.
• W2009457093 hasConcept C136764020 @default.
• W2009457093 hasConcept C159047783 @default.
• W2009457093 hasConcept C170493617 @default.
• W2009457093 hasConcept C2777427919 @default.
• W2009457093 hasConcept C2777625466 @default.
• W2009457093 hasConcept C41008148 @default.
• W2009457093 hasConcept C55493867 @default.
• W2009457093 hasConcept C71928629 @default.
• W2009457093 hasConcept C79879829 @default.
• W2009457093 hasConcept C86803240 @default.
• W2009457093 hasConcept C89423630 @default.
• W2009457093 hasConcept C95444343 @default.
• W2009457093 hasConceptScore W2009457093C104317684 @default.
• W2009457093 hasConceptScore W2009457093C112418997 @default.
• W2009457093 hasConceptScore W2009457093C129312508 @default.
• W2009457093 hasConceptScore W2009457093C136764020 @default.
• W2009457093 hasConceptScore W2009457093C159047783 @default.
• W2009457093 hasConceptScore W2009457093C170493617 @default.
• W2009457093 hasConceptScore W2009457093C2777427919 @default.
• W2009457093 hasConceptScore W2009457093C2777625466 @default.
• W2009457093 hasConceptScore W2009457093C41008148 @default.
• W2009457093 hasConceptScore W2009457093C55493867 @default.
• W2009457093 hasConceptScore W2009457093C71928629 @default.
• W2009457093 hasConceptScore W2009457093C79879829 @default.
• W2009457093 hasConceptScore W2009457093C86803240 @default.
• W2009457093 hasConceptScore W2009457093C89423630 @default.
• W2009457093 hasConceptScore W2009457093C95444343 @default.
• W2009457093 hasIssue "1" @default.
• W2009457093 hasLocation W20094570931 @default.
• W2009457093 hasLocation W20094570932 @default.
• W2009457093 hasLocation W20094570933 @default.
• W2009457093 hasLocation W20094570934 @default.
• W2009457093 hasOpenAccess W2009457093 @default.
• W2009457093 hasPrimaryLocation W20094570931 @default.
• W2009457093 hasRelatedWork W1558446731 @default.
• W2009457093 hasRelatedWork W1965911406 @default.
• W2009457093 hasRelatedWork W1991063996 @default.
• W2009457093 hasRelatedWork W2038147373 @default.
• W2009457093 hasRelatedWork W2100313298 @default.
• W2009457093 hasRelatedWork W2289546889 @default.
• W2009457093 hasRelatedWork W2805581803 @default.

• next