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- W2009457545 abstract "Abstract Inhibitors of arachidonic acid and epinephrine induced human platelet aggregation are described. The metabolic inhibitors 3-amino-1,2,4-triazole, sodium azide and sodium cyanide block arachidonic acid induced aggregation and the second phase of epinephrine induced aggregation but these agents do not block aggregation induced by exogenous ADP. Compounds acting at the alpha-receptor site, phentolamine and 6-hydroxydopamine, inhibit both the first and second phases of epinephrine induced aggregation but not arachidonic acid induced aggregation or aggregation induced by exogenous ADP. Dopamine also inhibits epinephrine induced aggregation without inhibiting either arachidonic acid or ADP induced aggregation. The dopaminergic blocking agent chlorpromazine behaves like 6-hydroxydopamine and dopamine in blocking epinephrine induced aggregation at lower concentrations but chlorpromazine at higher concentrations also blocks arachidonic acid and ADP induced aggregation." @default.
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- W2009457545 date "1975-12-01" @default.
- W2009457545 modified "2023-09-23" @default.
- W2009457545 title "Inhibition of platelet aggregation induced by either epinephrine or arachidonic acid" @default.
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- W2009457545 doi "https://doi.org/10.1016/0049-3848(75)90091-2" @default.
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