FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009461892> ?p ?o ?g. }

• W2009461892 endingPage "1132" @default.
• W2009461892 startingPage "1123" @default.
• W2009461892 abstract "Macrophages are among the infiltrate components of most malignant tumors. Tumor-associated macrophages (TAMs) may secrete a variety of humoral factors, which promote or inhibit tumor growth. In general, depending on their activation pathway, macrophages exhibit two different patterns of phenotype, M1 or M2. It is assumed that TAMs comprise pattern M2. In the malignant pleural effusion, macrophages are a frequent component of cytological evaluation. In this microenvironment, TAMs could be involved in the development of immunity. The phenotype of macrophages represented in malignant and non-malignant pleural effusions is unknown. In this study, macrophages were isolated from 38 pleural effusions (15 malignant and 23 non-malignant) and the expression of a variety of immune mediators and their receptors was assessed to determine the type of activation (M1 vs. M2). The expression of mRNA was analyzed for IL-1β, IL-4, IL-6, IL-10, IL-11, IL-18, TNFα, TGFβ1, IL1R1, IL1RAP, TLR2, TLR4, VLA4, CD62L, MMP2, MMP9, VEGFA, PDGFA, and PDGFB. In immunohistochemical evaluation, the expressions of CD68, mesothelin, MAC387, IL-1β, IL-6, IL-10, IL-12, TNFα, and CD105 were assessed. The cytoplasmic expression of IFNγ, TNFα, IL-6, and IL-10 and the surface expression of CD11a, CD14, CD15, CD16, CD23, CD25, CD45, CD54, CD62L, CD69, VLA2, VLA3, VLA4, VLA6, TLR2, TLR4, and CCR7 were tested using flow cytometry. In supernatants from macrophages cultures, TNFα, IL-1β, IL-6, IL-8, IL-10, IL-12, MCP1, and VEGF were investigated by cytometric beads array method (CBA flex sets) and TGFβ1 by ELISA. Our results indicate that macrophages from malignant and non-malignant pleural effusions differ from each other and suggest that macrophages isolated from non-malignant effusions show a pattern comparable to M1 while those isolated from malignant effusions express similarity to M2 phenotype, but they have not shown a classical M2 pattern." @default.
• W2009461892 created "2016-06-24" @default.
• W2009461892 creator A5023091967 @default.
• W2009461892 creator A5061665099 @default.
• W2009461892 creator A5065681889 @default.
• W2009461892 creator A5074187925 @default.
• W2009461892 creator A5086423741 @default.
• W2009461892 creator A5091382769 @default.
• W2009461892 date "2011-08-02" @default.
• W2009461892 modified "2023-10-18" @default.
• W2009461892 title "Evaluation of the phenotype pattern of macrophages isolated from malignant and non-malignant pleural effusions" @default.
• W2009461892 cites W1649938880 @default.
• W2009461892 cites W1963655045 @default.
• W2009461892 cites W1966342677 @default.
• W2009461892 cites W1976527118 @default.
• W2009461892 cites W1992537683 @default.
• W2009461892 cites W2003566453 @default.
• W2009461892 cites W2010285815 @default.
• W2009461892 cites W2015141049 @default.
• W2009461892 cites W2016293419 @default.
• W2009461892 cites W2020744745 @default.
• W2009461892 cites W2070971742 @default.
• W2009461892 cites W2073935157 @default.
• W2009461892 cites W2085599903 @default.
• W2009461892 cites W2089457438 @default.
• W2009461892 cites W2093705034 @default.
• W2009461892 cites W2149142217 @default.
• W2009461892 cites W4236509122 @default.
• W2009461892 doi "https://doi.org/10.1007/s13277-011-0214-1" @default.
• W2009461892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21809139" @default.
• W2009461892 hasPublicationYear "2011" @default.
• W2009461892 type Work @default.
• W2009461892 sameAs 2009461892 @default.
• W2009461892 citedByCount "25" @default.
• W2009461892 countsByYear W20094618922012 @default.
• W2009461892 countsByYear W20094618922013 @default.
• W2009461892 countsByYear W20094618922014 @default.
• W2009461892 countsByYear W20094618922015 @default.
• W2009461892 countsByYear W20094618922016 @default.
• W2009461892 countsByYear W20094618922017 @default.
• W2009461892 countsByYear W20094618922018 @default.
• W2009461892 countsByYear W20094618922020 @default.
• W2009461892 countsByYear W20094618922021 @default.
• W2009461892 countsByYear W20094618922022 @default.
• W2009461892 crossrefType "journal-article" @default.
• W2009461892 hasAuthorship W2009461892A5023091967 @default.
• W2009461892 hasAuthorship W2009461892A5061665099 @default.
• W2009461892 hasAuthorship W2009461892A5065681889 @default.
• W2009461892 hasAuthorship W2009461892A5074187925 @default.
• W2009461892 hasAuthorship W2009461892A5086423741 @default.
• W2009461892 hasAuthorship W2009461892A5091382769 @default.
• W2009461892 hasConcept C121608353 @default.
• W2009461892 hasConcept C126322002 @default.
• W2009461892 hasConcept C142724271 @default.
• W2009461892 hasConcept C17991360 @default.
• W2009461892 hasConcept C202751555 @default.
• W2009461892 hasConcept C203014093 @default.
• W2009461892 hasConcept C2775858924 @default.
• W2009461892 hasConcept C2776070231 @default.
• W2009461892 hasConcept C2779013556 @default.
• W2009461892 hasConcept C2779244956 @default.
• W2009461892 hasConcept C2780699576 @default.
• W2009461892 hasConcept C2781236682 @default.
• W2009461892 hasConcept C502942594 @default.
• W2009461892 hasConcept C55493867 @default.
• W2009461892 hasConcept C71924100 @default.
• W2009461892 hasConcept C86803240 @default.
• W2009461892 hasConcept C8891405 @default.
• W2009461892 hasConceptScore W2009461892C121608353 @default.
• W2009461892 hasConceptScore W2009461892C126322002 @default.
• W2009461892 hasConceptScore W2009461892C142724271 @default.
• W2009461892 hasConceptScore W2009461892C17991360 @default.
• W2009461892 hasConceptScore W2009461892C202751555 @default.
• W2009461892 hasConceptScore W2009461892C203014093 @default.
• W2009461892 hasConceptScore W2009461892C2775858924 @default.
• W2009461892 hasConceptScore W2009461892C2776070231 @default.
• W2009461892 hasConceptScore W2009461892C2779013556 @default.
• W2009461892 hasConceptScore W2009461892C2779244956 @default.
• W2009461892 hasConceptScore W2009461892C2780699576 @default.
• W2009461892 hasConceptScore W2009461892C2781236682 @default.
• W2009461892 hasConceptScore W2009461892C502942594 @default.
• W2009461892 hasConceptScore W2009461892C55493867 @default.
• W2009461892 hasConceptScore W2009461892C71924100 @default.
• W2009461892 hasConceptScore W2009461892C86803240 @default.
• W2009461892 hasConceptScore W2009461892C8891405 @default.
• W2009461892 hasIssue "6" @default.
• W2009461892 hasLocation W20094618921 @default.
• W2009461892 hasLocation W20094618922 @default.
• W2009461892 hasOpenAccess W2009461892 @default.
• W2009461892 hasPrimaryLocation W20094618921 @default.
• W2009461892 hasRelatedWork W2043331267 @default.
• W2009461892 hasRelatedWork W2056075233 @default.
• W2009461892 hasRelatedWork W2056385328 @default.
• W2009461892 hasRelatedWork W2220102944 @default.
• W2009461892 hasRelatedWork W2431806630 @default.
• W2009461892 hasRelatedWork W2577548098 @default.
• W2009461892 hasRelatedWork W3031852375 @default.
• W2009461892 hasRelatedWork W3112940496 @default.

• next