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- W2009461924 abstract "Methyl substitution on the indolic nitrogen and halogen substitution on the indole nucleus of tetrahydro-β-carbolines were found to facilitate the transport of compounds into the brain. A correlation between the brain accumulation, the pKa, and the partition coefficient has been made. The 8-chloro-9-methyl-1,2,3,4-tetrahydro-β-carboline was assayed with mitochondrial monoamine oxidase from mouse brain and liver. Its inhibitory activity was two-fold greater than that reported using bovine liver enzyme." @default.
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- W2009461924 date "1969-11-01" @default.
- W2009461924 modified "2023-09-25" @default.
- W2009461924 title "Inhibitors of Monoamine Oxidase V: Effect of Substitution on the Transport of Tetrahydro-β-Carboline Analogs to Mouse Brain" @default.
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- W2009461924 doi "https://doi.org/10.1002/jps.2600581132" @default.
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