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• W2009476656 abstract "The biogenesis of mitochondrial NADH:ubiquinone oxidoreductase (complex I) requires several assembly chaperones. These so-called complex I assembly factors have emerged as a new class of human disease genes. Here, we identified putative assembly factor homologues in Caenorhabditis elegans. We demonstrate that two candidates (C50B8.3/NUAF-1, homologue of NDUFAF1 and R07H5.3/NUAF-3, homologue of NDUFAF3) clearly affect complex I function. Assembly factor deficient worms were shorter, showed a diminished brood size and displayed reduced fat content. Our results suggest that mitochondrial complex I biogenesis is evolutionarily conserved. Moreover, Caenorhabditis elegans appears to be a promising model organism to study assembly factor related human diseases." @default.
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• W2009476656 date "2012-05-01" @default.
• W2009476656 modified "2023-10-14" @default.
• W2009476656 title "Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans" @default.
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• W2009476656 doi "https://doi.org/10.1016/j.mito.2012.01.003" @default.
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