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- W2009477675 abstract "Dacarbazine is a highly emetogenic drug leading to severe nausea and emesis in almost every patient in case no antiemetic treatment is given. Ninety patients with melanoma (Karnofsky index ≥70%) received dacarbazine chemotherapy during up to 14 courses of chemotherapy. As antiemetic prophylaxis, 5 or 10mg tropisetron was given once daily orally. During chemotherapy, the patients filled in diary cards reporting quality of life and general symptoms (well-being, sleep, nervousness, pain, mood, tiredness, food intake). In spite of treatment with a highly emetogenic drug, most patients rated quality of life good during several courses. General condition did not change significantly during treatment. Furthermore, normal food intake was maintained in most cases. We conclude that antiemetic prophylaxis with tropisetron helps to maintain quality of life and longterm well-being in patients receiving dacarbazine by effectively preventing the most distressing side effects of chemotherapy." @default.
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- W2009477675 date "1995-11-01" @default.
- W2009477675 modified "2023-09-25" @default.
- W2009477675 title "226 Long term quality of life in dacarbazine-treated patients receiving tropisetron prophylaxis" @default.
- W2009477675 doi "https://doi.org/10.1016/0959-8049(95)95484-n" @default.
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