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• W2009479213 abstract "Summary Female rats are more resistant to blood pressure increases induced by high salt ( HS ) intake or angiotensin (Ang) II infusion. Because endothelin ET B receptors on endothelial and epithelial cells mediate tonic vasodilation and sodium excretion, we hypothesized that ET B receptors limit the hypertensive response and renal injury induced by HS diet alone or with chronic Ang II infusion (Ang II / HS ) in female compared with male rats. A 4 week HS diet (4% NaCl) did not significantly change blood pressure (measured by telemetry) in either male or female Sprague‐Dawley rats. Administration of the ET B receptor antagonist A‐192621 (1, 3 and 10 mg/kg per day in food) during HS feeding caused a dose‐dependent increase in blood pressure in both sexes. In Ang II / HS rats, males had a larger increase in blood pressure than females. The increase in blood pressure produced by ET B receptor blockade in male Ang II / HS rats was not significant. However, A‐192621 treatment resulted in a significant further increase in blood pressure in female Ang II / HS rats. Male rats had consistently higher protein excretion rates before and during Ang II / HS , but this was not significantly affected by ET B receptor blockade in either sex. In conclusion, ET B receptors play a significantly greater beneficial role in protecting female compared with male rats against Ang II ‐induced hypertension and may contribute to the sex differences in Ang II ‐induced hypertension." @default.
• W2009479213 created "2016-06-24" @default.
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• W2009479213 date "2013-05-28" @default.
• W2009479213 modified "2023-10-17" @default.
• W2009479213 title "Endothelin ET_Breceptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet" @default.
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• W2009479213 doi "https://doi.org/10.1111/1440-1681.12084" @default.
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