FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009479964> ?p ?o ?g. }

• W2009479964 endingPage "2108" @default.
• W2009479964 startingPage "2098" @default.
• W2009479964 abstract "4-Arylamino and 2- cycloalkyl (including amino substitution) modifications were made in a series of 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the human A3 adenosine receptor (AR). In addition to allosteric modulation of the maximum functional efficacy (in [35S]GTPγS G protein binding assay) of the A3AR agonist Cl-IB-MECA (15), some analogues also weakly inhibited equilibrium radioligand binding at ARs. 4-(3,5-Dichlorophenylamino) (6) or 2-(1-adamantyl) (20) substitution produced allosteric enhancement (twice the maximal agonist efficacy), with minimal inhibition of orthosteric AR binding. 2-(4-Tetrahydropyranyl) substitution abolished allosteric enhancement but preserved inhibition of orthosteric binding. Introduction of nitrogen in the six-membered ring at the 2 position, to improve aqueous solubility and provide a derivatization site, greatly reduced the allosteric enhancement. 2-(4-(Benzoylamino)cyclohexyl) analogues 23 and 24 were weak negative A3AR modulators. Thus, consistent with previous findings, the allosteric and orthosteric inhibitory A3AR effects in imidazoquinolines are structurally separable, suggesting the possible design of additional derivatives with enhanced positive or negative allosteric A3AR activity and improved selectivity in comparison to inhibition of orthosteric binding." @default.
• W2009479964 created "2016-06-24" @default.
• W2009479964 creator A5036007966 @default.
• W2009479964 creator A5055538801 @default.
• W2009479964 creator A5065525958 @default.
• W2009479964 creator A5075179551 @default.
• W2009479964 creator A5091587615 @default.
• W2009479964 date "2009-03-13" @default.
• W2009479964 modified "2023-10-15" @default.
• W2009479964 title "Novel 2- and 4-Substituted 1<i>H</i>-Imidazo[4,5-<i>c</i>]quinolin-4-amine Derivatives as Allosteric Modulators of the A₃ Adenosine Receptor" @default.
• W2009479964 cites W1971472068 @default.
• W2009479964 cites W1976266427 @default.
• W2009479964 cites W1982944471 @default.
• W2009479964 cites W1985181088 @default.
• W2009479964 cites W1985598247 @default.
• W2009479964 cites W1990416730 @default.
• W2009479964 cites W1991255999 @default.
• W2009479964 cites W1994399278 @default.
• W2009479964 cites W2003366915 @default.
• W2009479964 cites W2044093685 @default.
• W2009479964 cites W2060765599 @default.
• W2009479964 cites W2074631079 @default.
• W2009479964 cites W2083217886 @default.
• W2009479964 cites W2090052077 @default.
• W2009479964 cites W2097058262 @default.
• W2009479964 cites W2099948396 @default.
• W2009479964 cites W2114710340 @default.
• W2009479964 cites W2153758876 @default.
• W2009479964 cites W2156912338 @default.
• W2009479964 cites W2166225079 @default.
• W2009479964 cites W2734663543 @default.
• W2009479964 cites W4293247451 @default.
• W2009479964 doi "https://doi.org/10.1021/jm801659w" @default.
• W2009479964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2765805" @default.
• W2009479964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19284749" @default.
• W2009479964 hasPublicationYear "2009" @default.
• W2009479964 type Work @default.
• W2009479964 sameAs 2009479964 @default.
• W2009479964 citedByCount "35" @default.
• W2009479964 countsByYear W20094799642012 @default.
• W2009479964 countsByYear W20094799642013 @default.
• W2009479964 countsByYear W20094799642015 @default.
• W2009479964 countsByYear W20094799642016 @default.
• W2009479964 countsByYear W20094799642017 @default.
• W2009479964 countsByYear W20094799642018 @default.
• W2009479964 countsByYear W20094799642019 @default.
• W2009479964 countsByYear W20094799642020 @default.
• W2009479964 countsByYear W20094799642021 @default.
• W2009479964 countsByYear W20094799642022 @default.
• W2009479964 crossrefType "journal-article" @default.
• W2009479964 hasAuthorship W2009479964A5036007966 @default.
• W2009479964 hasAuthorship W2009479964A5055538801 @default.
• W2009479964 hasAuthorship W2009479964A5065525958 @default.
• W2009479964 hasAuthorship W2009479964A5075179551 @default.
• W2009479964 hasAuthorship W2009479964A5091587615 @default.
• W2009479964 hasBestOaLocation W20094799642 @default.
• W2009479964 hasConcept C107824862 @default.
• W2009479964 hasConcept C166342909 @default.
• W2009479964 hasConcept C170493617 @default.
• W2009479964 hasConcept C182683403 @default.
• W2009479964 hasConcept C185592680 @default.
• W2009479964 hasConcept C2776038425 @default.
• W2009479964 hasConcept C2778938600 @default.
• W2009479964 hasConcept C55493867 @default.
• W2009479964 hasConcept C67847695 @default.
• W2009479964 hasConcept C67907053 @default.
• W2009479964 hasConcept C71240020 @default.
• W2009479964 hasConceptScore W2009479964C107824862 @default.
• W2009479964 hasConceptScore W2009479964C166342909 @default.
• W2009479964 hasConceptScore W2009479964C170493617 @default.
• W2009479964 hasConceptScore W2009479964C182683403 @default.
• W2009479964 hasConceptScore W2009479964C185592680 @default.
• W2009479964 hasConceptScore W2009479964C2776038425 @default.
• W2009479964 hasConceptScore W2009479964C2778938600 @default.
• W2009479964 hasConceptScore W2009479964C55493867 @default.
• W2009479964 hasConceptScore W2009479964C67847695 @default.
• W2009479964 hasConceptScore W2009479964C67907053 @default.
• W2009479964 hasConceptScore W2009479964C71240020 @default.
• W2009479964 hasIssue "7" @default.
• W2009479964 hasLocation W20094799641 @default.
• W2009479964 hasLocation W20094799642 @default.
• W2009479964 hasLocation W20094799643 @default.
• W2009479964 hasLocation W20094799644 @default.
• W2009479964 hasOpenAccess W2009479964 @default.
• W2009479964 hasPrimaryLocation W20094799641 @default.
• W2009479964 hasRelatedWork W1985181088 @default.
• W2009479964 hasRelatedWork W2001643841 @default.
• W2009479964 hasRelatedWork W2021374990 @default.
• W2009479964 hasRelatedWork W2032228733 @default.
• W2009479964 hasRelatedWork W2073648757 @default.
• W2009479964 hasRelatedWork W2082296334 @default.
• W2009479964 hasRelatedWork W2153758876 @default.
• W2009479964 hasRelatedWork W2166225079 @default.
• W2009479964 hasRelatedWork W2315687448 @default.
• W2009479964 hasRelatedWork W2908579861 @default.
• W2009479964 hasVolume "52" @default.
• W2009479964 isParatext "false" @default.
• W2009479964 isRetracted "false" @default.

• next