Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009482382> ?p ?o ?g. }
- W2009482382 endingPage "559" @default.
- W2009482382 startingPage "545" @default.
- W2009482382 abstract "Matrix adhesions provide critical signals for cell growth or differentiation. They form through a number of distinct steps that follow integrin binding to matrix ligands. In an early step, integrins form clusters that support actin polymerization by an unknown mechanism. This raises the question of how actin polymerization occurs at the integrin clusters. We report here that a major formin in mouse fibroblasts, FHOD1, is recruited to integrin clusters, resulting in actin assembly. Using cell-spreading assays on lipid bilayers, solid substrates, and high-resolution force-sensing pillar arrays, we find that knockdown of FHOD1 impairs spreading, coordinated application of adhesive force, and adhesion maturation. Finally, we show that targeting of FHOD1 to the integrin sites depends on the direct interaction with Src family kinases and is upstream of the activation by Rho kinase. Thus, our findings provide insights into the mechanisms of cell migration with implications for development and disease." @default.
- W2009482382 created "2016-06-24" @default.
- W2009482382 creator A5003148736 @default.
- W2009482382 creator A5007197576 @default.
- W2009482382 creator A5017118872 @default.
- W2009482382 creator A5040193425 @default.
- W2009482382 creator A5058882814 @default.
- W2009482382 creator A5059881323 @default.
- W2009482382 creator A5062353668 @default.
- W2009482382 creator A5075445640 @default.
- W2009482382 creator A5085179815 @default.
- W2009482382 date "2013-12-01" @default.
- W2009482382 modified "2023-10-16" @default.
- W2009482382 title "FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration" @default.
- W2009482382 cites W1489785912 @default.
- W2009482382 cites W1748924892 @default.
- W2009482382 cites W1978677736 @default.
- W2009482382 cites W1979038578 @default.
- W2009482382 cites W1987139499 @default.
- W2009482382 cites W1987384052 @default.
- W2009482382 cites W1990722779 @default.
- W2009482382 cites W1991549216 @default.
- W2009482382 cites W1995846053 @default.
- W2009482382 cites W1999250555 @default.
- W2009482382 cites W1999707554 @default.
- W2009482382 cites W2007719816 @default.
- W2009482382 cites W2008343636 @default.
- W2009482382 cites W2015422987 @default.
- W2009482382 cites W2018966115 @default.
- W2009482382 cites W2025823358 @default.
- W2009482382 cites W2032116260 @default.
- W2009482382 cites W2032392940 @default.
- W2009482382 cites W2033728878 @default.
- W2009482382 cites W2034716886 @default.
- W2009482382 cites W2044788731 @default.
- W2009482382 cites W2047366865 @default.
- W2009482382 cites W2047691928 @default.
- W2009482382 cites W2055390022 @default.
- W2009482382 cites W2067202475 @default.
- W2009482382 cites W2068701052 @default.
- W2009482382 cites W2074003465 @default.
- W2009482382 cites W2077603983 @default.
- W2009482382 cites W2079270430 @default.
- W2009482382 cites W2079548558 @default.
- W2009482382 cites W2081833813 @default.
- W2009482382 cites W2091393415 @default.
- W2009482382 cites W2094173028 @default.
- W2009482382 cites W2095625881 @default.
- W2009482382 cites W2103835571 @default.
- W2009482382 cites W2105188443 @default.
- W2009482382 cites W2105789974 @default.
- W2009482382 cites W2111432848 @default.
- W2009482382 cites W2111719518 @default.
- W2009482382 cites W2120446093 @default.
- W2009482382 cites W2126015832 @default.
- W2009482382 cites W2127735672 @default.
- W2009482382 cites W2131444686 @default.
- W2009482382 cites W2134224050 @default.
- W2009482382 cites W2146667247 @default.
- W2009482382 cites W2148820834 @default.
- W2009482382 cites W2152462023 @default.
- W2009482382 cites W2152884138 @default.
- W2009482382 cites W2156193902 @default.
- W2009482382 cites W2160518415 @default.
- W2009482382 cites W2160912589 @default.
- W2009482382 cites W2161272336 @default.
- W2009482382 cites W2164682544 @default.
- W2009482382 cites W2171572138 @default.
- W2009482382 cites W4376848286 @default.
- W2009482382 cites W2560693326 @default.
- W2009482382 doi "https://doi.org/10.1016/j.devcel.2013.11.003" @default.
- W2009482382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3890431" @default.
- W2009482382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24331927" @default.
- W2009482382 hasPublicationYear "2013" @default.
- W2009482382 type Work @default.
- W2009482382 sameAs 2009482382 @default.
- W2009482382 citedByCount "98" @default.
- W2009482382 countsByYear W20094823822014 @default.
- W2009482382 countsByYear W20094823822015 @default.
- W2009482382 countsByYear W20094823822016 @default.
- W2009482382 countsByYear W20094823822017 @default.
- W2009482382 countsByYear W20094823822018 @default.
- W2009482382 countsByYear W20094823822019 @default.
- W2009482382 countsByYear W20094823822020 @default.
- W2009482382 countsByYear W20094823822021 @default.
- W2009482382 countsByYear W20094823822022 @default.
- W2009482382 countsByYear W20094823822023 @default.
- W2009482382 crossrefType "journal-article" @default.
- W2009482382 hasAuthorship W2009482382A5003148736 @default.
- W2009482382 hasAuthorship W2009482382A5007197576 @default.
- W2009482382 hasAuthorship W2009482382A5017118872 @default.
- W2009482382 hasAuthorship W2009482382A5040193425 @default.
- W2009482382 hasAuthorship W2009482382A5058882814 @default.
- W2009482382 hasAuthorship W2009482382A5059881323 @default.
- W2009482382 hasAuthorship W2009482382A5062353668 @default.
- W2009482382 hasAuthorship W2009482382A5075445640 @default.
- W2009482382 hasAuthorship W2009482382A5085179815 @default.
- W2009482382 hasBestOaLocation W20094823821 @default.