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• W2009484911 abstract "Objectifs – Les auteurs ont réalisé une étude multicentrique, randomisée, en double aveugle, pour comparer un traitement de cinq jours de céfuroxime axetil 250 mg deux fois/j par rapport à dix jours de ce même traitement sur des critères cliniques, radiologiques et bactériologiques.Patients et méthodes – 401 patients adultes souffrant d'une sinusite maxillaire aiguë définie par au moins deux symptômes cliniques et confirmée par la radiographie ont été inclus entre janvier 1997 et janvier 1998. Les patients recevaient soit du céfuroxime axetil 250 mg deux fois/j pendant cinq jours suivi de 5 jours de placebo soit du céfuroxime axetil 250 mg deux fois/j pendant dix jours.Résultats – Dans l'analyse en Intention de Traiter, les taux de succès clinique étaient équivalents (85% et de 87% respectivement pour les groupes cinq et dix jours) avec une différence des taux de succès égal à −1,2%; IC90% : [−6,9%; 4,5%]. En fin de suivi : une rechute clinique était survenue chez 51 patients (respectivement 25 et 26 patients des groupes cinq et dix jours); une normalisation/amélioration radiologique était obtenue chez 68% et 67% des patients respectivement pour les groupes cinq et dix jours. Les principaux germes isolés à l'inclusion étaient S. pneumoniae (n = 60), H. influenzae (n = 56), M. catarrhalis (n = 22). En fin de traitement, 89% des patients du groupe cinq jours et 91% du groupe dix jours étaient en succès bactériologique; en fin d'essai, 83% et 78% des patients respectivement pour les groupes cinq et dix jours.Conclusion – Cette étude confirme le profil de tolérance du céfuroxime axetil. Dans le traitement des sinusites maxillaires aiguës, cinq jours de céfuroxime axetil 250 mg deux fois/j a une efficacité équivalente à dix jours de ce même traitement sur des critères cliniques, radiologiques et bactériologiques.Objective – The aim of this double blind, randomized, multicenter study carried out by 78 ENT specialists was to demonstrate that the two regimens (five days versus ten days) of cefuroxime axetil 250 mg twice daily present the same clinical efficacy in adults with acute maxillary sinusitis.Patients and methods – Diagnosis of sinusitis was defined as at least two of the following symptoms (purulent rhinorrhea, nasal congestion, headache, facial pain), and radiologically confirmed by an expert committee. Clinical efficacy, defined as success (cure or improvement) or failure, was assessed at the end of treatment (days 12–14) and on follow-up (days 21–28). A total of 401 patients (206 for the five-day group, 195 for the ten-day group) were randomized between January 1997 and January 1998. All patients were assessed for safety analysis, Intent-to-Treat and Per-Protocol analysis.Results – The most commonly isolated pre-treatment pathogens were S. pneumoniae (n = 60), H. influenzae (n = 56), and M. catarrhalis (n = 22). At the end of treatment, clinical success rates were equivalent, with 85% (176/206) in the five-day group and 87% (169/195) in the ten-day group. The difference in success rates was −1.2% with a 90%CI: [−6.9%; 4.5%]. On follow-up, 51 patients experienced a clinical relapse : 25 and 26 patients in the in the five-day group and ten-day group respectively. Radiological success rate on follow-up was 68% in the five-day group and 67% in the ten-day group. Bacteriological success rate was 89% and 91% in the five-day group and ten-day group respectively at end of treatment; it was 83% and 78% in the five-day group and ten-day group respectively on follow-up. No unexpected adverse event was observed and both regimens were well tolerated.Conclusion – A five-day course of cefuroxime 250mg twice daily is as effective as a ten-day course in the treatment of acute bacterial sinusitis." @default.
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• W2009484911 title "Prise en charge de la sinusite aiguë en France en pratique médicale courante" @default.
• W2009484911 doi "https://doi.org/10.1016/j.respe.2007.07.039" @default.
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