Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009490070> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2009490070 endingPage "434" @default.
- W2009490070 startingPage "427" @default.
- W2009490070 abstract "Objective. To investigate the distribution and production of alpha1-antichymotrypsin (ACT) and prostate-specific antigen (PSA) in benign hyperplastic and malignant prostatic tissue, respectively. Methods. Using monoclonal anti-ACT and anti-PSA IgGs for immunocytochemistry and alkaline phosphatase conjugated 30-mer oligodeoxynucleotide probes for nonradioactive in situ hybridization, tissue specimens were studied from 15 patients with benign prostatic hyperplasia after transurethral resection of the prostate (TURP) and from 9 patients with bladder cancer who underwent cystoprostatectomy. Cancer specimens were from 23 TURP patients and from ultrasound guided core biopsies in 14 patients. Prostate tumors were graded according to the Gleason system. Results. We found no or only occasional small foci of immunostaining for ACT, and no ACT transcripts in the PSA-producing epithelium in areas with benign nodular hyperplasia. By contrast, a high proportion of cells expressed both ACT and PSA in prostate cancers with low Gleason score, as detected by immunocytochemistry and in situ hybridization. Poorly differentiated tumor cells manifested greater variation in immunostaining for both ACT and PSA. As compared to tumors of low Gleason score, high-score tumors less frequently manifested immunostaining for ACT than for PSA, and less frequently generated hybridization signals for both PSA and ACT transcripts. Conclusions. A significantly higher proportion of serum PSA has been reported to be complexed to ACT in patients with prostate cancer than in patients with benign prostatic hyperplasia. The presently reported lack of ACT production in PSA-containing BPH nodules may contribute to this by making conditions less optimal for complex formation between PSA and ACT As opposed to this, production of both ACT and PSA in prostate cancers may enhance the complex formation between PSA and ACT." @default.
- W2009490070 created "2016-06-24" @default.
- W2009490070 creator A5015634061 @default.
- W2009490070 creator A5020495334 @default.
- W2009490070 creator A5043570965 @default.
- W2009490070 creator A5053247634 @default.
- W2009490070 creator A5056770711 @default.
- W2009490070 creator A5088952792 @default.
- W2009490070 date "1994-04-01" @default.
- W2009490070 modified "2023-10-17" @default.
- W2009490070 title "Alpha1-antichymotrypsin production in PSA-producing cells is common in prostate cancer but rare in benign prostatc hyperplasia" @default.
- W2009490070 cites W1845134010 @default.
- W2009490070 cites W1847856759 @default.
- W2009490070 cites W1865508414 @default.
- W2009490070 cites W1963764466 @default.
- W2009490070 cites W1999995892 @default.
- W2009490070 cites W2013695861 @default.
- W2009490070 cites W2019490921 @default.
- W2009490070 cites W2028113711 @default.
- W2009490070 cites W2048483596 @default.
- W2009490070 cites W2048750477 @default.
- W2009490070 cites W2051582871 @default.
- W2009490070 cites W2060860221 @default.
- W2009490070 cites W2061734101 @default.
- W2009490070 cites W2124314287 @default.
- W2009490070 cites W2273833263 @default.
- W2009490070 cites W2330292521 @default.
- W2009490070 cites W38427941 @default.
- W2009490070 doi "https://doi.org/10.1016/0090-4295(94)90225-9" @default.
- W2009490070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7519383" @default.
- W2009490070 hasPublicationYear "1994" @default.
- W2009490070 type Work @default.
- W2009490070 sameAs 2009490070 @default.
- W2009490070 citedByCount "128" @default.
- W2009490070 countsByYear W20094900702012 @default.
- W2009490070 countsByYear W20094900702014 @default.
- W2009490070 countsByYear W20094900702016 @default.
- W2009490070 countsByYear W20094900702019 @default.
- W2009490070 countsByYear W20094900702020 @default.
- W2009490070 crossrefType "journal-article" @default.
- W2009490070 hasAuthorship W2009490070A5015634061 @default.
- W2009490070 hasAuthorship W2009490070A5020495334 @default.
- W2009490070 hasAuthorship W2009490070A5043570965 @default.
- W2009490070 hasAuthorship W2009490070A5053247634 @default.
- W2009490070 hasAuthorship W2009490070A5056770711 @default.
- W2009490070 hasAuthorship W2009490070A5088952792 @default.
- W2009490070 hasConcept C121608353 @default.
- W2009490070 hasConcept C126322002 @default.
- W2009490070 hasConcept C126894567 @default.
- W2009490070 hasConcept C142724271 @default.
- W2009490070 hasConcept C204232928 @default.
- W2009490070 hasConcept C2776235491 @default.
- W2009490070 hasConcept C2777562237 @default.
- W2009490070 hasConcept C2780192828 @default.
- W2009490070 hasConcept C2781406297 @default.
- W2009490070 hasConcept C35866371 @default.
- W2009490070 hasConcept C4224716 @default.
- W2009490070 hasConcept C71924100 @default.
- W2009490070 hasConcept C87874733 @default.
- W2009490070 hasConceptScore W2009490070C121608353 @default.
- W2009490070 hasConceptScore W2009490070C126322002 @default.
- W2009490070 hasConceptScore W2009490070C126894567 @default.
- W2009490070 hasConceptScore W2009490070C142724271 @default.
- W2009490070 hasConceptScore W2009490070C204232928 @default.
- W2009490070 hasConceptScore W2009490070C2776235491 @default.
- W2009490070 hasConceptScore W2009490070C2777562237 @default.
- W2009490070 hasConceptScore W2009490070C2780192828 @default.
- W2009490070 hasConceptScore W2009490070C2781406297 @default.
- W2009490070 hasConceptScore W2009490070C35866371 @default.
- W2009490070 hasConceptScore W2009490070C4224716 @default.
- W2009490070 hasConceptScore W2009490070C71924100 @default.
- W2009490070 hasConceptScore W2009490070C87874733 @default.
- W2009490070 hasIssue "4" @default.
- W2009490070 hasLocation W20094900701 @default.
- W2009490070 hasLocation W20094900702 @default.
- W2009490070 hasOpenAccess W2009490070 @default.
- W2009490070 hasPrimaryLocation W20094900701 @default.
- W2009490070 hasRelatedWork W1546665496 @default.
- W2009490070 hasRelatedWork W2047254492 @default.
- W2009490070 hasRelatedWork W2058336691 @default.
- W2009490070 hasRelatedWork W2064110992 @default.
- W2009490070 hasRelatedWork W2077965718 @default.
- W2009490070 hasRelatedWork W2109873888 @default.
- W2009490070 hasRelatedWork W2352355015 @default.
- W2009490070 hasRelatedWork W2377951033 @default.
- W2009490070 hasRelatedWork W2392701383 @default.
- W2009490070 hasRelatedWork W31383154 @default.
- W2009490070 hasVolume "43" @default.
- W2009490070 isParatext "false" @default.
- W2009490070 isRetracted "false" @default.
- W2009490070 magId "2009490070" @default.
- W2009490070 workType "article" @default.