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- W2009491154 abstract "This chapter discusses the structural classification, synthesis, biological activity, and natural sources of stemona alkaloids. The Stemona alkaloids are structurally characterized by the presence of either an exposed or hidden pyrrolo[1,2-a]azepine (n=1) moiety, also named perhydroazaazulene or 4-aza-azulene, or a pyrido[1,2-a]azepine (n=2) nucleus and currently comprises 68 alkaloids. The biological activities of some Stemona alkaloids are evaluated in order to find the active principles of Stemona species. Tuberostemonine was the first Stemona alkaloid to have its biological activity tested. The anthelminthic activity of this alkaloid was detected against Angiostrongylus cantonensis, Dipylidium caninun, and Fasciola hepatica with an effect on the motility of these helminthic worms. Tuberostemonine was pointed out as the bioactive principle responsible for the insecticidal activity of S. tuberosa, with activity levels comparable to those of azadirachtin, after being tested against the larvae of Spodoptera littoralis. The action of tuberostemonine on the neuromuscular transmission in crayfish was also investigated, revealing that this alkaloid depressed glutamate-induced responses at similar concentrations of those of established glutamate inhibitors. The Stemonaceae is so far the only source of the Stemona alkaloids." @default.
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- W2009491154 date "2005-01-01" @default.
- W2009491154 modified "2023-10-18" @default.
- W2009491154 title "The Stemona Alkaloids" @default.
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- W2009491154 doi "https://doi.org/10.1016/s1099-4831(05)62002-0" @default.
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