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- W2009503462 abstract "Abstract Retrotransposons are mobile genetic elements, and their mobility can lead to genomic instability. Retrotransposon insertions are associated with a diverse range of sporadic diseases, including cancer. Thus, it is not a surprise that multiple host defense mechanisms suppress retrotransposition. The 2′,5′-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is a mechanism for restricting viral infections during the interferon antiviral response. Here, we investigated a potential role for the OAS-RNase L system in the restriction of retrotransposons. Expression of wild type (WT) and a constitutively active form of RNase L (NΔ385), but not a catalytically inactive RNase L mutant (R667A), impaired the mobility of engineered human LINE-1 (L1) and mouse intracisternal A-type particle retrotransposons in cultured human cells. Furthermore, WT RNase L, but not an inactive RNase L mutant (R667A), reduced L1 RNA levels and subsequent expression of the L1-encoded proteins (ORF1p and ORF2p). Consistently, confocal immunofluorescent microscopy demonstrated that WT RNase L, but not RNase L R667A, prevented formation of L1 cytoplasmic foci. Finally, siRNA-mediated depletion of endogenous RNase L in a human ovarian cancer cell line (Hey1b) increased the levels of L1 retrotransposition by ∼2-fold. Together, these data suggest that RNase L might function as a suppressor of structurally distinct retrotransposons." @default.
- W2009503462 created "2016-06-24" @default.
- W2009503462 creator A5016025349 @default.
- W2009503462 creator A5059509650 @default.
- W2009503462 creator A5065430631 @default.
- W2009503462 creator A5067358586 @default.
- W2009503462 creator A5070946467 @default.
- W2009503462 creator A5073965149 @default.
- W2009503462 date "2013-12-25" @default.
- W2009503462 modified "2023-10-01" @default.
- W2009503462 title "RNase L restricts the mobility of engineered retrotransposons in cultured human cells" @default.
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