FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009509211> ?p ?o ?g. }

• W2009509211 endingPage "163" @default.
• W2009509211 startingPage "156" @default.
• W2009509211 abstract "In Eastern cultures, such as India, it is traditionally recommended that women but not men cover their heads while working in the scorching sun. The purpose of this pilot study was to determine whether there was any scientific basis for this cultural tradition. We examined the differential cytotoxic effects of ultraviolet A light (UVA) on an established T cell line treated with female and male sex hormones. CD4+ Jurkat T cells were plated in 96 well plates at 2 x 106 cells/ml and treated with 17β-estradiol (EST) or testosterone (TE). These cells were irradiated by UVA light with an irradiance of 170 J/cm2 for 15min at a distance of 6 cm from the surface of the 96-well plate. Controls included cells not treated with hormones or UVA. The effects of EST and TE were investigated between 1 and 20 ng/mL. Cytotoxicity by fluorescein-diacetate staining and COMET assay generating single strand DNA cleavage, tail length and tail moment measurements were examined. The effect of estrogen (5ng/mL) on apoptosis and its mediators was further studied using DNA laddering and western blotting for bcl-2 and p53. We found that EST alone, without UVA, enhanced Jurkat T cell survival. However, EST exhibited a dose-related cytotoxicity in the presence of UVA; up to 28% at 20 ng/ml. TE did not alter UVA-induced cytotoxicity. Since TE did not alter cell viability in the presence of UVA further damaging studies were not performed. COMET assay demonstrated the harmful effects of EST in the presence of UVA while EST without UVA had no significant effect on the nuclear damage. Apoptosis was not present as indicated by the absence of DNA laddering on agarose gel electrophoresis at 5ng/ml EST or TE ± UVA. Western blot showed that estrogen down regulated bcl-2 independently of UVA radiation while p53 was down regulated in the presence of UVA treatment. EST and TE have differential effects on UVA-induced cytotoxicity in Jurkat T-lymphocyte which suggested that women may be more susceptible to the harmful effects of solar irradiation than men." @default.
• W2009509211 created "2016-06-24" @default.
• W2009509211 creator A5021809675 @default.
• W2009509211 creator A5033413781 @default.
• W2009509211 creator A5034195164 @default.
• W2009509211 creator A5042481555 @default.
• W2009509211 creator A5073022518 @default.
• W2009509211 creator A5074138884 @default.
• W2009509211 creator A5074185619 @default.
• W2009509211 creator A5080547719 @default.
• W2009509211 date "2005-04-30" @default.
• W2009509211 modified "2023-10-17" @default.
• W2009509211 title "Effect of Light Irradiation and Sex Hormones on Jurkat T Cells: 17β-Estradiol but Not Testosterone Enhances UVA-Induced Cytotoxicity in Jurkat Lymphocytes" @default.
• W2009509211 cites W1835927651 @default.
• W2009509211 cites W1847864430 @default.
• W2009509211 cites W1969542989 @default.
• W2009509211 cites W1970546664 @default.
• W2009509211 cites W1974556834 @default.
• W2009509211 cites W1977131610 @default.
• W2009509211 cites W1977686001 @default.
• W2009509211 cites W1977754085 @default.
• W2009509211 cites W1986179131 @default.
• W2009509211 cites W1991209501 @default.
• W2009509211 cites W1991247489 @default.
• W2009509211 cites W1991253583 @default.
• W2009509211 cites W2024290133 @default.
• W2009509211 cites W2024437197 @default.
• W2009509211 cites W2030031867 @default.
• W2009509211 cites W2042871686 @default.
• W2009509211 cites W2042977262 @default.
• W2009509211 cites W2054955905 @default.
• W2009509211 cites W2058529953 @default.
• W2009509211 cites W2058591356 @default.
• W2009509211 cites W2064214182 @default.
• W2009509211 cites W2078209244 @default.
• W2009509211 cites W2082259697 @default.
• W2009509211 cites W2089829661 @default.
• W2009509211 cites W2090239878 @default.
• W2009509211 cites W2096757580 @default.
• W2009509211 cites W2100130506 @default.
• W2009509211 cites W2107100887 @default.
• W2009509211 cites W2107416858 @default.
• W2009509211 cites W2108895176 @default.
• W2009509211 cites W2116835488 @default.
• W2009509211 cites W2123447369 @default.
• W2009509211 cites W2145421358 @default.
• W2009509211 cites W2148166852 @default.
• W2009509211 cites W2186358774 @default.
• W2009509211 cites W2405766927 @default.
• W2009509211 cites W2429595548 @default.
• W2009509211 doi "https://doi.org/10.3390/ijerph2005010156" @default.
• W2009509211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814710" @default.
• W2009509211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16705813" @default.
• W2009509211 hasPublicationYear "2005" @default.
• W2009509211 type Work @default.
• W2009509211 sameAs 2009509211 @default.
• W2009509211 citedByCount "3" @default.
• W2009509211 countsByYear W20095092112015 @default.
• W2009509211 crossrefType "journal-article" @default.
• W2009509211 hasAuthorship W2009509211A5021809675 @default.
• W2009509211 hasAuthorship W2009509211A5033413781 @default.
• W2009509211 hasAuthorship W2009509211A5034195164 @default.
• W2009509211 hasAuthorship W2009509211A5042481555 @default.
• W2009509211 hasAuthorship W2009509211A5073022518 @default.
• W2009509211 hasAuthorship W2009509211A5074138884 @default.
• W2009509211 hasAuthorship W2009509211A5074185619 @default.
• W2009509211 hasAuthorship W2009509211A5080547719 @default.
• W2009509211 hasBestOaLocation W20095092111 @default.
• W2009509211 hasConcept C109316439 @default.
• W2009509211 hasConcept C134018914 @default.
• W2009509211 hasConcept C143425029 @default.
• W2009509211 hasConcept C153911025 @default.
• W2009509211 hasConcept C154317977 @default.
• W2009509211 hasConcept C179464577 @default.
• W2009509211 hasConcept C185592680 @default.
• W2009509211 hasConcept C190283241 @default.
• W2009509211 hasConcept C202751555 @default.
• W2009509211 hasConcept C203014093 @default.
• W2009509211 hasConcept C2776090121 @default.
• W2009509211 hasConcept C2777164284 @default.
• W2009509211 hasConcept C2779279991 @default.
• W2009509211 hasConcept C2780358455 @default.
• W2009509211 hasConcept C53227056 @default.
• W2009509211 hasConcept C552990157 @default.
• W2009509211 hasConcept C55493867 @default.
• W2009509211 hasConcept C86803240 @default.
• W2009509211 hasConcept C8891405 @default.
• W2009509211 hasConceptScore W2009509211C109316439 @default.
• W2009509211 hasConceptScore W2009509211C134018914 @default.
• W2009509211 hasConceptScore W2009509211C143425029 @default.
• W2009509211 hasConceptScore W2009509211C153911025 @default.
• W2009509211 hasConceptScore W2009509211C154317977 @default.
• W2009509211 hasConceptScore W2009509211C179464577 @default.
• W2009509211 hasConceptScore W2009509211C185592680 @default.
• W2009509211 hasConceptScore W2009509211C190283241 @default.
• W2009509211 hasConceptScore W2009509211C202751555 @default.
• W2009509211 hasConceptScore W2009509211C203014093 @default.
• W2009509211 hasConceptScore W2009509211C2776090121 @default.

• next