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- W2009511069 abstract "Backgrounds: It has been extremely difficult to detect superficial neoplastic lesions (NLs), including dysplasia and sqamous cell carcinoma in an earlier stage, at oropharyngeal and hypopharyngeal sites during routine endoscopy. Furthermore, even if the superficial NLs can be pointed out, it has not been established to differentiate NLs from non-neoplastic lesions (non-NLs) in the present. Aim: The present study aim was to clarify characteristic endoscopic findings of the superficial NLs at the oropharyngeal and hypopharyngeal sites. Methods: We undertook endoscopy for 71 patients due to screening / surveillance or work-up for squamous cell carcinoma of the head and neck or the esophagus. Biopsy specimens were obtained from 106 lesions at oropharyngeal and hypopharyngeal sites. Findings of conventional endoscopy and magnifying endoscopy with NBI system (MENBI) at those sites were compared with those histological findings. Results: Histological findings of 61 non-NLs showed normal mucosa: 3; inflammatory change: 38; sqamous cell hyperplasia: 13; papilloma: 7. In addition, histological findings of 45 NLs demonstrated superficial sqamous cell carcinoma (SCC ≦ T1): 35; high-grade dysplasia: 4; low-grade dysplasia: 6. Both frequencies of reddish and flat lesions (P = 0.001 and 0.003) in NLs were significantly higher than those in non-NLs under a conventional endoscopic observation. Univariate analysis for 5 kinds of MENBI findings demonstrated that brownish-epithelium of interspaced capillaries, dilatation, proliferation, irregularity and frog egg like appearance of superficial capillaries in NLs were significantly more frequent than those in non-NLs, respectively. On multivariate analysis, proliferation (P = 0.009) and irregularity (P = 0.0016) of capillaries were independent factors for diagnosing NLs by MENBI. Conclusions: MENBI was useful for diagnosing superficial NLs at oropharyngeal and hypopharyngeal sites. It is suggested that important characteristic findings in the NLs under the MENBI were proliferation and irregularity of superficial capillaries." @default.
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- W2009511069 date "2006-04-01" @default.
- W2009511069 modified "2023-09-26" @default.
- W2009511069 title "Clinical Significance of Magnifying Endoscopy Combined with Narrow Band Imaging System for Neoplastic Lesions At Oropharyngeal and Hypopharyngeal Sites" @default.
- W2009511069 doi "https://doi.org/10.1016/j.gie.2006.03.134" @default.
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