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- W2009523618 abstract "Abstract Objective —To determine efficacy of propofol as an immersion agent to induce general anesthesia in koi ( Cyprinus carpio ). Design —Prospective, crossover study. Animals —10 adult koi (mean ± SD weight, 325 ± 81 g). Procedures —Koi were exposed to each of 4 concentrations of propofol (1, 2.5, 5, and 10 mg/L) with a 1-week washout period between trials. In a subsequent trial, koi were anesthetized with propofol (5 mg/L) and anesthesia was maintained with propofol (3 mg/L) for 20 minutes. Response to a noxious stimulus was assessed by means of needle insertion into an epaxial muscle. Results —At a propofol concentration of 1 mg/L, koi were sedated but never anesthetized. At propofol concentrations of 2.5, 5, and 10 mg/L, mean ± SD anesthetic induction times were 13.4 ± 3.3, 3.8 ± 1.1, and 2.3 ± 0.9 minutes, respectively; mean recovery times were 12.9 ± 8.3, 11.0 ± 6.3, and 18.1 ± 13.0 minutes; mean heart rates were 57 ± 25, 30 ± 14, and 22 ± 14 beats/min; mean opercular rates were 58 ± 18, 68 ± 15, and 48 ± 22 beats/min; and 1 of 10, 2 of 10, and 0 of 10 fish responded to needle insertion. All fish recovered satisfactorily. Following 20 minutes of anesthesia, 2 fish had recovery times > 4 hours and 1 fish died. Conclusions and Clinical Relevance —Immersion in propofol at concentrations ≥ 2.5 mg/L induced general anesthesia in koi. Maintenance of anesthesia with propofol for 20 minutes was associated with prolonged recovery times in 2 of 9 and death in 1 of 9 koi." @default.
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- W2009523618 date "2014-12-01" @default.
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- W2009523618 title "Physiologic and biochemical assessments of koi (<i>Cyprinus carpio</i>) following immersion in propofol" @default.
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- W2009523618 doi "https://doi.org/10.2460/javma.245.11.1286" @default.
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