FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009548698> ?p ?o ?g. }

• W2009548698 endingPage "2979" @default.
• W2009548698 startingPage "2969" @default.
• W2009548698 abstract "A role for the transcription factor JunB in proliferation control was investigated in genetically modified mouse fibroblasts. Increased JunB expression induced high levels of the cyclin-dependent kinase inhibitor p16(INK4a), leading to premature senescence in primary cells and reduced proliferation in 3T3 cells, whereas lack of JunB expression results in decreased p16 levels. Furthermore, JunB-mediated p16 induction in 3T3 cells completely abolished cyclin D-associated kinase activity, resulting in reduced pRb hyperphosphorylation and G(1)-phase extension. Moreover, three AP1-like binding sites were identified in the p16 promoter through which JunB directly activates p16 transcription. Elevated JunB expression in 3T3 cells also inhibited Ras- and Src-mediated transformation and tumour growth in vivo. The suppressive effect of JunB on cell proliferation was shown to be dependent on p16 since it did not occur in INK4a(-/-) fibroblasts that lack both p16 and p19(ARF). These results demonstrate that p16 is a direct transcriptional target gene of JunB and identify JunB as a negative regulator of cell proliferation." @default.
• W2009548698 created "2016-06-24" @default.
• W2009548698 creator A5004832527 @default.
• W2009548698 creator A5016128169 @default.
• W2009548698 date "2000-06-15" @default.
• W2009548698 modified "2023-10-14" @default.
• W2009548698 title "JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression" @default.
• W2009548698 cites W134790102 @default.
• W2009548698 cites W1481473039 @default.
• W2009548698 cites W1811606715 @default.
• W2009548698 cites W1845790496 @default.
• W2009548698 cites W1956646665 @default.
• W2009548698 cites W1963522337 @default.
• W2009548698 cites W1973812603 @default.
• W2009548698 cites W1984361597 @default.
• W2009548698 cites W1986660515 @default.
• W2009548698 cites W1986763150 @default.
• W2009548698 cites W1987453246 @default.
• W2009548698 cites W1999330214 @default.
• W2009548698 cites W2015066175 @default.
• W2009548698 cites W2016929854 @default.
• W2009548698 cites W2036224418 @default.
• W2009548698 cites W2040616051 @default.
• W2009548698 cites W2040703859 @default.
• W2009548698 cites W2049085719 @default.
• W2009548698 cites W2063746249 @default.
• W2009548698 cites W2068728258 @default.
• W2009548698 cites W2069691728 @default.
• W2009548698 cites W2083906966 @default.
• W2009548698 cites W2087586960 @default.
• W2009548698 cites W2101937406 @default.
• W2009548698 cites W2102563680 @default.
• W2009548698 cites W2103924217 @default.
• W2009548698 cites W2104908670 @default.
• W2009548698 cites W2112294647 @default.
• W2009548698 cites W2115692032 @default.
• W2009548698 cites W2146035452 @default.
• W2009548698 cites W2166529745 @default.
• W2009548698 cites W2169413646 @default.
• W2009548698 cites W2315355727 @default.
• W2009548698 cites W2413459115 @default.
• W2009548698 cites W2418627005 @default.
• W2009548698 cites W4290209684 @default.
• W2009548698 doi "https://doi.org/10.1093/emboj/19.12.2969" @default.
• W2009548698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/203376" @default.
• W2009548698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10856241" @default.
• W2009548698 hasPublicationYear "2000" @default.
• W2009548698 type Work @default.
• W2009548698 sameAs 2009548698 @default.
• W2009548698 citedByCount "289" @default.
• W2009548698 countsByYear W20095486982012 @default.
• W2009548698 countsByYear W20095486982013 @default.
• W2009548698 countsByYear W20095486982014 @default.
• W2009548698 countsByYear W20095486982015 @default.
• W2009548698 countsByYear W20095486982016 @default.
• W2009548698 countsByYear W20095486982017 @default.
• W2009548698 countsByYear W20095486982018 @default.
• W2009548698 countsByYear W20095486982019 @default.
• W2009548698 countsByYear W20095486982020 @default.
• W2009548698 countsByYear W20095486982021 @default.
• W2009548698 countsByYear W20095486982022 @default.
• W2009548698 countsByYear W20095486982023 @default.
• W2009548698 crossrefType "journal-article" @default.
• W2009548698 hasAuthorship W2009548698A5004832527 @default.
• W2009548698 hasAuthorship W2009548698A5016128169 @default.
• W2009548698 hasBestOaLocation W20095486982 @default.
• W2009548698 hasConcept C102280478 @default.
• W2009548698 hasConcept C104317684 @default.
• W2009548698 hasConcept C120089663 @default.
• W2009548698 hasConcept C1491633281 @default.
• W2009548698 hasConcept C153911025 @default.
• W2009548698 hasConcept C199835354 @default.
• W2009548698 hasConcept C2776746612 @default.
• W2009548698 hasConcept C2777099045 @default.
• W2009548698 hasConcept C2781085546 @default.
• W2009548698 hasConcept C29537977 @default.
• W2009548698 hasConcept C502942594 @default.
• W2009548698 hasConcept C54009773 @default.
• W2009548698 hasConcept C54355233 @default.
• W2009548698 hasConcept C62112901 @default.
• W2009548698 hasConcept C81885089 @default.
• W2009548698 hasConcept C86339819 @default.
• W2009548698 hasConcept C86803240 @default.
• W2009548698 hasConcept C88045685 @default.
• W2009548698 hasConcept C95444343 @default.
• W2009548698 hasConceptScore W2009548698C102280478 @default.
• W2009548698 hasConceptScore W2009548698C104317684 @default.
• W2009548698 hasConceptScore W2009548698C120089663 @default.
• W2009548698 hasConceptScore W2009548698C1491633281 @default.
• W2009548698 hasConceptScore W2009548698C153911025 @default.
• W2009548698 hasConceptScore W2009548698C199835354 @default.
• W2009548698 hasConceptScore W2009548698C2776746612 @default.
• W2009548698 hasConceptScore W2009548698C2777099045 @default.
• W2009548698 hasConceptScore W2009548698C2781085546 @default.
• W2009548698 hasConceptScore W2009548698C29537977 @default.
• W2009548698 hasConceptScore W2009548698C502942594 @default.
• W2009548698 hasConceptScore W2009548698C54009773 @default.
• W2009548698 hasConceptScore W2009548698C54355233 @default.

• next