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- W2009550082 abstract "The binding of estradiol and progesterone to the corresponding antibodies has been studied in system containing: a) antibody and hormone or b) antibody, hormone and rat plasma. In system a) the apparent association constant and the concentration of the antibody have been determined and the optimal conditions of a standard antibodyassay have been elaborated. In system b) the specific binding of hormone to antibody in presence of rat plasma has been measured, and the value of the «Operational Association Constant, KOP, has been calculated. KOP has the dimensions of an apparent association constant: it defines the ratio hormone bound/unbound to antibody, as a function of hormone concentration in system b). Based upon these experiments, the extent of hormone-binding to antibody injected to rats can be predicted. When antibody and hormone concentrations are measured in the plasma, the concentrations of hormone bound to antibody can be calculated. Lorsqu'on injecte à des rates des anticorps antiœstradiol ou anti-progestérone, l'effet biologique de ces hormones est « neutralisé . Afin d'interpréter quantitativement les résultats, la fixation de ces hormones sur l'anticorps correspondant a été étudiée dans deux systèmes contenant: A) anticorps et hormone; B) anticorps, hormone et plasma de rate. Dans le système A la constante d'association apparente (KAapp) de l'anticorps a été déterminée et les conditions optimales d'un dosage de routine de l'anticorps ont été établies. Dans le système B la valeur d'une constante empirique, Kop, a été déterminée. Kop a les dimensions d'une KAapp, permettant de calculer la concentration plasmatique en hormone non fixée par l'anticorps en fonction de la concentration totale mesurée dans le plasma. Ces données permettent certaines prédictions concernant l'expérience biologique et l'interprétation quantitative des résultats obtenus." @default.
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- W2009550082 date "1976-05-01" @default.
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- W2009550082 title "The parameters of the binding of estradiol and progesterone to their antibodies in presence of rat plasma" @default.
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- W2009550082 doi "https://doi.org/10.1016/s0300-9084(76)80256-8" @default.
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