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- W2009553313 abstract "Cystic hygromas (CH) are anomalies of the lymphatic system and in almost 70% of cases are associated with chromosomal aberrations. F2-isoprostanes are isomers of the prostaglandin F2a produced by ROS attack on polyunsatured fatty acid. They are chemically stable, sensitive and specific quantitative biomarkers of lipid peroxidation in-vitro and in-vivo. The aim of this study was to evaluate the levels of amniotic fluid F2-isoprostanes in normal pregnancies and in those with cystic hygroma. F2-isoprostane levels were measured by colorimetric enzyme immunoassay in the amniotic fluid of 77 normal pregnancies (14–18 weeks; chromosomally normal and without anatomical defects) and 17 pregnancies with CH (gestational age range, 11–15 weeks). Fetal karyotype was analyzed in all cases by amniocentesis. The presence of septa within the hygroma, of hydrops and other fetal anomalies was investigated by ultrasound. Compared to normal pregnancies, isoprostane levels were significantly higher in fetuses with chromosomal aberrations and hydrops, and in fetuses with a normal karyotype and hydrops. Normal levels of isoprostanes were found in fetuses with CH without hydrops, resulting in liveborn healthy babies. Measurement of isoprostane levels could be a prognostic factor among fetuses with CH and a normal karyotype. Common use of this predictive marker in obstetrics may improve the ability of clinicians to identify fetuses developing hydrops and at high risk of intrauterine fetal death." @default.
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- W2009553313 date "2007-09-21" @default.
- W2009553313 modified "2023-09-27" @default.
- W2009553313 title "OC282: Amniotic fluid isoprostane levels in fetuses with cystic hygroma" @default.
- W2009553313 doi "https://doi.org/10.1002/uog.4388" @default.
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