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• W2009553780 abstract "Abstract Androgen receptors (ARs) from fish were characterized in order to evaluate differences in the binding affinities of steroids and environmental chemicals between mammals and fish, among species offish, and among target tissues within a species of fish. High‐affinity, low‐capacity ARs were identified in cytosolic fractions of rainbow trout brains ( Oncorhynchus mykiss ) and the brains, ovaries, and testes of goldfish ( Carassius auratus ) using [ 3 H]testosterone. The binding specificities of endogenous steroids to the ARs did not differ between goldfish tissues but did differ between goldfish and rainbow trout. Interspecies differences in binding specificities were also seen using cyproterone acetate, which bound to the ARs in the goldfish tissues, but not in the rainbow trout brains. The mammalian antiandrogens flutamide, vinclozolin and its metabolites 2‐(((3,5)‐dichlorophenyl‐carbamo‐yl)oxy)‐2‐methyl‐3‐butenoic acid and 3′,5′‐dichloro‐2‐hydroxy‐2‐methylbut‐3‐enanilide, along with procymidone did not bind to the ARs in any of the fish tissues tested. However, other mammalian antiandrogens including methoxychlor and its metabolite 2,2‐bis( p ‐hydroxyphenyl)‐1,1,1‐trichloroethane, o,p ′‐DDT, o,p ′‐dichlorodiphenyldichloroethylene (DDE) and p,p ′‐DDE did bind to the fish ARs, but only in the goldfish testes, demonstrating tissue differences in AR binding specificities of environmental chemicals. These results may be due to the presence of multiple AR isoforms in the different fish species and tissues. This study supports the growing evidence of species differences in the potency and actions of endocrine‐disrupting chemicals and suggests that multiple species need to be tested when screening the receptor binding ability of potential endocrine‐disrupting chemicals." @default.
• W2009553780 created "2016-06-24" @default.
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• W2009553780 date "2000-08-01" @default.
• W2009553780 modified "2023-10-18" @default.
• W2009553780 title "Differential binding of endogenous steroids and chemicals to androgen receptors in rainbow trout and goldfish" @default.
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• W2009553780 doi "https://doi.org/10.1002/etc.5620190814" @default.
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