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• W2009554780 abstract "Well-characterized, monomeric, lathyritic tropocollagen and a variety of well-characterized glycosaminoglycan preparations have been used in turbidimetric studies on collagen fiber formation in vitro. The experiments have been performed under physiological ionic conditions and at 37°C. It has been shown by others that the fibrillogenetic process consists of two stages, a nucleation phase and a fiber growth phase. By addition of polysaccharides before and after the nucleation phase it was possible to differentiate between the effects of the polysaccharides on the nucleation and on the fiber-growth, respectively. Chondroitin sulphate, dermatan sulphate, heparan sulphate, heparin and proteoglycans of chondroitin sulphate and dermatan sulphate, which at 4°C form complexes with tropocollagen, in most cases accelerated the fiber formation, when they were added before the nucleation phase. This phenomenon was ascribed to an effect on the nucleation process. When added after the nucleation phase chondroitin sulphate, a heparan sulphate fraction and especially the proteoglycans delayed the fiber formation. This observation was ascribed to an inhibition of fiber growth from the nuclei. Hyaluronic acid, which increases the activity of the tropocollagen molecules by steric exclusion, accelerated both the nucleation and the fiber growth processes. Keratan sulphate, which does not form complexes with collagen, had no or a slightly decelerating effect, either when added before or after the nucleation. It could be demonstrated by light-scattering technique that certain glycosaminoglycans influenced the properties of the collagen fibrils formed during the early fiber formation process. The observation that certain polysaccharides had different effects on collagen fiber formation, when added before or after the nucleation, shows that the state of aggregation (nucleation) of collagen is of prime importance in determining the effects exerted by the polysaccharides. This finding may explain some of the contradictory data in the literature. Chemical and physical heterogeneity of the glycosaminoglycans also influenced their mode of interaction with collagen during fiber formation." @default.
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• W2009554780 date "1973-04-01" @default.
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• W2009554780 title "The Influence of Glycosaminoglycans on the Formation of Fibers from Monomeric Tropocollagen in vitro" @default.
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• W2009554780 doi "https://doi.org/10.1111/j.1432-1033.1973.tb02739.x" @default.
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