Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009557907> ?p ?o ?g. }
- W2009557907 endingPage "890" @default.
- W2009557907 startingPage "882" @default.
- W2009557907 abstract "Iron chelators have dramatically prolonged the life expectancy of patients with transfusion-dependent thalassaemia, but their precise clinical benefit in reducing the myocardial iron burden and improving cardiac function is unknown. This systematic review and meta-analysis included published clinical trials that assessed the efficacy of iron chelators in regularly transfused patients of thalassaemia major for two commonly reported outcomes - myocardial iron content and left ventricular ejection fraction (LVEF). The meta-analysis of 392 patients for myocardial iron content and 291 patients for LVEF showed that (i) iron chelators reduced cardiac iron content by 23.9% (95% confidence interval 17.3-29.8%); (ii) there was no significant difference between the amount of iron reduced by deferoxamine and deferiprone (P = 0.9504); and (iii) LVEF was not significantly influenced by iron chelators - summary Hedge's g 0.13 (95% confidence interval -0.10-0.36). A significant publication bias existed for LVEF (Egger's P = 0.049) but not for myocardial iron (Egger's P = 0.871). Our results indicate that iron chelators significantly reduce myocardial iron content. Further, the choice of deferoxamine versus deferiprone may rest on factors other than their efficacy to reduce cardiac iron load." @default.
- W2009557907 created "2016-06-24" @default.
- W2009557907 creator A5018883009 @default.
- W2009557907 creator A5020806539 @default.
- W2009557907 date "2008-04-22" @default.
- W2009557907 modified "2023-10-15" @default.
- W2009557907 title "Influence of iron chelators on myocardial iron and cardiac function in transfusion‐dependent thalassaemia: a systematic review and meta‐analysis" @default.
- W2009557907 cites W172096104 @default.
- W2009557907 cites W1964990513 @default.
- W2009557907 cites W1971308630 @default.
- W2009557907 cites W1973162291 @default.
- W2009557907 cites W1975105587 @default.
- W2009557907 cites W1977745350 @default.
- W2009557907 cites W1981998167 @default.
- W2009557907 cites W1983330639 @default.
- W2009557907 cites W1987331450 @default.
- W2009557907 cites W1995255139 @default.
- W2009557907 cites W2019433045 @default.
- W2009557907 cites W2027084618 @default.
- W2009557907 cites W2032775105 @default.
- W2009557907 cites W2034494510 @default.
- W2009557907 cites W2043396435 @default.
- W2009557907 cites W2049877822 @default.
- W2009557907 cites W2052066512 @default.
- W2009557907 cites W2055148131 @default.
- W2009557907 cites W2061647004 @default.
- W2009557907 cites W2061877805 @default.
- W2009557907 cites W2062187126 @default.
- W2009557907 cites W2067697375 @default.
- W2009557907 cites W2070992644 @default.
- W2009557907 cites W2071208608 @default.
- W2009557907 cites W2077429231 @default.
- W2009557907 cites W2078922684 @default.
- W2009557907 cites W2079108765 @default.
- W2009557907 cites W2082283198 @default.
- W2009557907 cites W2084049152 @default.
- W2009557907 cites W2091283210 @default.
- W2009557907 cites W2106579993 @default.
- W2009557907 cites W2110713267 @default.
- W2009557907 cites W2120041716 @default.
- W2009557907 cites W2120213563 @default.
- W2009557907 cites W2126930838 @default.
- W2009557907 cites W2146921545 @default.
- W2009557907 cites W2153558385 @default.
- W2009557907 cites W2155063465 @default.
- W2009557907 cites W2155790709 @default.
- W2009557907 cites W2156237444 @default.
- W2009557907 cites W2157823046 @default.
- W2009557907 cites W2168793485 @default.
- W2009557907 cites W2317072972 @default.
- W2009557907 cites W2324532843 @default.
- W2009557907 doi "https://doi.org/10.1111/j.1365-2141.2008.07122.x" @default.
- W2009557907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355381" @default.
- W2009557907 hasPublicationYear "2008" @default.
- W2009557907 type Work @default.
- W2009557907 sameAs 2009557907 @default.
- W2009557907 citedByCount "32" @default.
- W2009557907 countsByYear W20095579072012 @default.
- W2009557907 countsByYear W20095579072013 @default.
- W2009557907 countsByYear W20095579072014 @default.
- W2009557907 countsByYear W20095579072016 @default.
- W2009557907 countsByYear W20095579072017 @default.
- W2009557907 countsByYear W20095579072018 @default.
- W2009557907 countsByYear W20095579072021 @default.
- W2009557907 crossrefType "journal-article" @default.
- W2009557907 hasAuthorship W2009557907A5018883009 @default.
- W2009557907 hasAuthorship W2009557907A5020806539 @default.
- W2009557907 hasBestOaLocation W20095579071 @default.
- W2009557907 hasConcept C111566952 @default.
- W2009557907 hasConcept C126322002 @default.
- W2009557907 hasConcept C164705383 @default.
- W2009557907 hasConcept C2776517179 @default.
- W2009557907 hasConcept C2776672577 @default.
- W2009557907 hasConcept C2777799968 @default.
- W2009557907 hasConcept C2778198053 @default.
- W2009557907 hasConcept C44249647 @default.
- W2009557907 hasConcept C71924100 @default.
- W2009557907 hasConcept C78085059 @default.
- W2009557907 hasConcept C95190672 @default.
- W2009557907 hasConceptScore W2009557907C111566952 @default.
- W2009557907 hasConceptScore W2009557907C126322002 @default.
- W2009557907 hasConceptScore W2009557907C164705383 @default.
- W2009557907 hasConceptScore W2009557907C2776517179 @default.
- W2009557907 hasConceptScore W2009557907C2776672577 @default.
- W2009557907 hasConceptScore W2009557907C2777799968 @default.
- W2009557907 hasConceptScore W2009557907C2778198053 @default.
- W2009557907 hasConceptScore W2009557907C44249647 @default.
- W2009557907 hasConceptScore W2009557907C71924100 @default.
- W2009557907 hasConceptScore W2009557907C78085059 @default.
- W2009557907 hasConceptScore W2009557907C95190672 @default.
- W2009557907 hasIssue "6" @default.
- W2009557907 hasLocation W20095579071 @default.
- W2009557907 hasLocation W20095579072 @default.
- W2009557907 hasOpenAccess W2009557907 @default.
- W2009557907 hasPrimaryLocation W20095579071 @default.
- W2009557907 hasRelatedWork W1838884915 @default.
- W2009557907 hasRelatedWork W2022232491 @default.
- W2009557907 hasRelatedWork W2071208608 @default.