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- W2009559062 abstract "The analysis of homovanillic acid (HVA) in serum of humans and goats is described for the first time. The method uses gas chromatographic separation and mass spectrometric detection with the deuterated methyl ester of HVA as an internal standard. Simultaneous measurement of the protium and deuterium forms was performed with a multiple ion detector focused at the molecular ions of the methyl ester heptaflurobutyryl derivatives. The method has high specificity, a precision of ±10% (S.E.) and a sensitivity which determines normal levels (100 pmole/ml) at 10 times above the background. The serum level in man was increased several fold following physical exercise. In goats probenecid elevated the level of HVA, whereas nialamide had the opposite effect." @default.
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- W2009559062 date "1973-10-01" @default.
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- W2009559062 title "Quantitative determination of homovanillic acid in serum by mass fragmentography" @default.
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- W2009559062 doi "https://doi.org/10.1016/0014-2999(73)90111-8" @default.
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