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- W2009560845 endingPage "1366" @default.
- W2009560845 startingPage "1349" @default.
- W2009560845 abstract "Introduction: The NMDA receptor mediates a slow component of excitatory synaptic transmission, and NMDA receptor dysfunction has been implicated in numerous neurological disorders. Thus, interest in developing modulators that are capable of regulating the channel continues to be strong. Recent research has led to the discovery of a number of compounds that hold therapeutic and clinical value. Deeper insight into the NMDA intersubunit interactions and structural motifs gleaned from the recently solved crystal structures of the NMDA receptor should facilitate a deeper understanding of how these compounds modulate the receptor.Areas covered: This article discusses the known pharmacology of NMDA receptors. A discussion of the patent literature since 2012 is also included, with an emphasis on those that claimed new chemical entities as regulators of the NMDA receptor.Expert opinion: The number of patents involving novel NMDA receptor modulators suggests a renewed interest in the NMDA receptor as a therapeutic target. Subunit-selective modulators continue to show promise, and the development of new subunit-selective NMDA receptor modulators appears poised for continued growth. Although a modest number of channel blocker patents were published, successful clinical outcomes involving ketamine have led to a resurgent interest in low-affinity channel blockers as therapeutics." @default.
- W2009560845 created "2016-06-24" @default.
- W2009560845 creator A5023563915 @default.
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- W2009560845 creator A5041161550 @default.
- W2009560845 creator A5045171998 @default.
- W2009560845 creator A5066323135 @default.
- W2009560845 date "2014-10-29" @default.
- W2009560845 modified "2023-09-23" @default.
- W2009560845 title "NMDA receptor modulators: an updated patent review (2013 – 2014)" @default.
- W2009560845 cites W1483876599 @default.
- W2009560845 cites W1531160152 @default.
- W2009560845 cites W1551685198 @default.
- W2009560845 cites W1595726542 @default.
- W2009560845 cites W1606744897 @default.
- W2009560845 cites W1656913045 @default.
- W2009560845 cites W1824863696 @default.
- W2009560845 cites W1876061808 @default.
- W2009560845 cites W1888844436 @default.
- W2009560845 cites W1898334791 @default.
- W2009560845 cites W1918304474 @default.
- W2009560845 cites W1956388268 @default.
- W2009560845 cites W1964764373 @default.
- W2009560845 cites W1966515122 @default.
- W2009560845 cites W1969686168 @default.
- W2009560845 cites W1971899172 @default.
- W2009560845 cites W1974642350 @default.
- W2009560845 cites W1975522748 @default.
- W2009560845 cites W1975780147 @default.
- W2009560845 cites W1981604957 @default.
- W2009560845 cites W1982314170 @default.
- W2009560845 cites W1992465104 @default.
- W2009560845 cites W1994681591 @default.
- W2009560845 cites W1995776925 @default.
- W2009560845 cites W1998347917 @default.
- W2009560845 cites W1999061814 @default.
- W2009560845 cites W2000300989 @default.
- W2009560845 cites W2000494198 @default.
- W2009560845 cites W2002287054 @default.
- W2009560845 cites W2007726238 @default.
- W2009560845 cites W2007906244 @default.
- W2009560845 cites W2009473514 @default.
- W2009560845 cites W2009971242 @default.
- W2009560845 cites W2010926499 @default.
- W2009560845 cites W2012641732 @default.
- W2009560845 cites W2012968801 @default.
- W2009560845 cites W2018249613 @default.
- W2009560845 cites W2019196831 @default.
- W2009560845 cites W2022317515 @default.
- W2009560845 cites W2024380057 @default.
- W2009560845 cites W2025607405 @default.
- W2009560845 cites W2026730082 @default.
- W2009560845 cites W2028805622 @default.
- W2009560845 cites W2029093606 @default.
- W2009560845 cites W2029922642 @default.
- W2009560845 cites W2032560275 @default.
- W2009560845 cites W2033697764 @default.
- W2009560845 cites W2033963948 @default.
- W2009560845 cites W2035487071 @default.
- W2009560845 cites W2037762739 @default.
- W2009560845 cites W2037852973 @default.
- W2009560845 cites W2043263332 @default.
- W2009560845 cites W2044958998 @default.
- W2009560845 cites W2045130274 @default.
- W2009560845 cites W2047397795 @default.
- W2009560845 cites W2049022403 @default.
- W2009560845 cites W2049055721 @default.
- W2009560845 cites W2049369336 @default.
- W2009560845 cites W2049563161 @default.
- W2009560845 cites W2051909860 @default.
- W2009560845 cites W2054596536 @default.
- W2009560845 cites W2056422818 @default.
- W2009560845 cites W2056891103 @default.
- W2009560845 cites W2056969868 @default.
- W2009560845 cites W2057823004 @default.
- W2009560845 cites W2058659255 @default.
- W2009560845 cites W2060050678 @default.
- W2009560845 cites W2061675143 @default.
- W2009560845 cites W2065169750 @default.
- W2009560845 cites W2068568993 @default.
- W2009560845 cites W2069359718 @default.
- W2009560845 cites W2070275362 @default.
- W2009560845 cites W2071713888 @default.
- W2009560845 cites W2072878669 @default.
- W2009560845 cites W2075752641 @default.
- W2009560845 cites W2077348695 @default.
- W2009560845 cites W2078167209 @default.
- W2009560845 cites W2079524104 @default.
- W2009560845 cites W2080519186 @default.
- W2009560845 cites W2081535550 @default.
- W2009560845 cites W2083681242 @default.
- W2009560845 cites W2084120702 @default.
- W2009560845 cites W2084290400 @default.
- W2009560845 cites W2084494940 @default.
- W2009560845 cites W2086688096 @default.
- W2009560845 cites W2086968249 @default.
- W2009560845 cites W2088307620 @default.
- W2009560845 cites W2089094370 @default.