FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009570912> ?p ?o ?g. }

• W2009570912 endingPage "1886" @default.
• W2009570912 startingPage "1877" @default.
• W2009570912 abstract "<h3>Objectives:</h3> We previously reported that daclizumab, a humanized monoclonal antibody against CD25, reduced contrast-enhancing lesions (CEL) in patients with multiple sclerosis (MS) who were suboptimal responders to interferon-β and that this response correlated with expansion of CD56^bright NK cells. These data have been reproduced in a placebo-controlled multicenter trial (CHOICE study). The current study investigates whether daclizumab monotherapy reduces CEL in untreated patients with relapsing-remitting MS (RRMS) and the effects of daclizumab on the intrathecal immune system. <h3>Methods:</h3> Sixteen patients with RRMS with high inflammatory activity were enrolled in an open-label, baseline-vs-treatment, phase II trial of daclizumab monotherapy for 54 weeks and followed by serial clinical and MRI examinations and immunologic biomarkers measured in the whole blood and CSF. <h3>Results:</h3> The trial achieved predefined outcomes. There was an 87.7% reduction in brain CEL (primary) and improvements in Multiple Sclerosis Functional Composite (secondary), Scripps Neurologic Rating Scale, and Expanded Disability Status Scale (tertiary) outcomes. There was significant expansion of CD56^bright NK cells in peripheral blood and CSF, with resultant decrease in T cells/NK cells and B cells/NK cells ratios and IL-12p40 in the CSF. Surprisingly, CD25 Tac epitope was equally blocked on the immune cells in the CSF and in peripheral blood. <h3>Conclusions:</h3> Daclizumab monotherapy inhibits formation of MS plaques in patients with RRMS and immunoregulatory NK cells may suppress activation of pathogenic immune responses directly in the CNS compartment. <h3>Classification of evidence:</h3> The study provides Class III evidence that daclizumab reduces the number of contrast-enhancing lesions in treatment-naive patients with RRMS over a 54-week period." @default.
• W2009570912 created "2016-06-24" @default.
• W2009570912 creator A5002151766 @default.
• W2009570912 creator A5013296652 @default.
• W2009570912 creator A5013620880 @default.
• W2009570912 creator A5035996420 @default.
• W2009570912 creator A5054950406 @default.
• W2009570912 creator A5075869834 @default.
• W2009570912 creator A5078826738 @default.
• W2009570912 creator A5080215421 @default.
• W2009570912 date "2011-11-09" @default.
• W2009570912 modified "2023-10-07" @default.
• W2009570912 title "Intrathecal effects of daclizumab treatment of multiple sclerosis" @default.
• W2009570912 cites W180656536 @default.
• W2009570912 cites W1973432972 @default.
• W2009570912 cites W1977375752 @default.
• W2009570912 cites W1977547355 @default.
• W2009570912 cites W1977849209 @default.
• W2009570912 cites W1980808173 @default.
• W2009570912 cites W1984999645 @default.
• W2009570912 cites W1996481500 @default.
• W2009570912 cites W2000061964 @default.
• W2009570912 cites W2039255804 @default.
• W2009570912 cites W2051992221 @default.
• W2009570912 cites W2058688962 @default.
• W2009570912 cites W2061374640 @default.
• W2009570912 cites W2064687595 @default.
• W2009570912 cites W2066334802 @default.
• W2009570912 cites W2097025094 @default.
• W2009570912 cites W2104878804 @default.
• W2009570912 cites W2105490558 @default.
• W2009570912 cites W2108398194 @default.
• W2009570912 cites W2112165124 @default.
• W2009570912 cites W2113485611 @default.
• W2009570912 cites W2113754168 @default.
• W2009570912 cites W2114942536 @default.
• W2009570912 cites W2121931605 @default.
• W2009570912 cites W2126778627 @default.
• W2009570912 cites W2142820307 @default.
• W2009570912 cites W2149898467 @default.
• W2009570912 cites W2163200333 @default.
• W2009570912 cites W2165362561 @default.
• W2009570912 cites W2168122373 @default.
• W2009570912 cites W2169082675 @default.
• W2009570912 doi "https://doi.org/10.1212/wnl.0b013e318239f7ef" @default.
• W2009570912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3246406" @default.
• W2009570912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22076546" @default.
• W2009570912 hasPublicationYear "2011" @default.
• W2009570912 type Work @default.
• W2009570912 sameAs 2009570912 @default.
• W2009570912 citedByCount "81" @default.
• W2009570912 countsByYear W20095709122012 @default.
• W2009570912 countsByYear W20095709122013 @default.
• W2009570912 countsByYear W20095709122014 @default.
• W2009570912 countsByYear W20095709122015 @default.
• W2009570912 countsByYear W20095709122016 @default.
• W2009570912 countsByYear W20095709122017 @default.
• W2009570912 countsByYear W20095709122018 @default.
• W2009570912 countsByYear W20095709122019 @default.
• W2009570912 countsByYear W20095709122020 @default.
• W2009570912 countsByYear W20095709122021 @default.
• W2009570912 countsByYear W20095709122022 @default.
• W2009570912 countsByYear W20095709122023 @default.
• W2009570912 crossrefType "journal-article" @default.
• W2009570912 hasAuthorship W2009570912A5002151766 @default.
• W2009570912 hasAuthorship W2009570912A5013296652 @default.
• W2009570912 hasAuthorship W2009570912A5013620880 @default.
• W2009570912 hasAuthorship W2009570912A5035996420 @default.
• W2009570912 hasAuthorship W2009570912A5054950406 @default.
• W2009570912 hasAuthorship W2009570912A5075869834 @default.
• W2009570912 hasAuthorship W2009570912A5078826738 @default.
• W2009570912 hasAuthorship W2009570912A5080215421 @default.
• W2009570912 hasBestOaLocation W20095709122 @default.
• W2009570912 hasConcept C126322002 @default.
• W2009570912 hasConcept C159654299 @default.
• W2009570912 hasConcept C203014093 @default.
• W2009570912 hasConcept C2776090121 @default.
• W2009570912 hasConcept C2779719350 @default.
• W2009570912 hasConcept C2780640218 @default.
• W2009570912 hasConcept C2780892749 @default.
• W2009570912 hasConcept C2908698914 @default.
• W2009570912 hasConcept C2994247566 @default.
• W2009570912 hasConcept C542903549 @default.
• W2009570912 hasConcept C71924100 @default.
• W2009570912 hasConcept C79484868 @default.
• W2009570912 hasConcept C8891405 @default.
• W2009570912 hasConceptScore W2009570912C126322002 @default.
• W2009570912 hasConceptScore W2009570912C159654299 @default.
• W2009570912 hasConceptScore W2009570912C203014093 @default.
• W2009570912 hasConceptScore W2009570912C2776090121 @default.
• W2009570912 hasConceptScore W2009570912C2779719350 @default.
• W2009570912 hasConceptScore W2009570912C2780640218 @default.
• W2009570912 hasConceptScore W2009570912C2780892749 @default.
• W2009570912 hasConceptScore W2009570912C2908698914 @default.
• W2009570912 hasConceptScore W2009570912C2994247566 @default.
• W2009570912 hasConceptScore W2009570912C542903549 @default.
• W2009570912 hasConceptScore W2009570912C71924100 @default.
• W2009570912 hasConceptScore W2009570912C79484868 @default.

• next