FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009572451> ?p ?o ?g. }

• W2009572451 endingPage "131" @default.
• W2009572451 startingPage "116" @default.
• W2009572451 abstract "The atrial natriuretic factor (ANF) gene is initially expressed throughout the myocardial layer of the heart, but during subsequent development, expression becomes limited to the atrial chambers. Mouse knockout and mammalian cell culture studies have shown that the ANF gene is regulated by combinatorial interactions between Nkx2-5, GATA-4, Tbx5, and SRF; however, the molecular mechanisms leading to chamber-specific expression are currently unknown. We have isolated the Xenopus ANF promoter in order to examine the temporal and spatial regulation of the ANF gene in vivo using transgenic embryos. The mammalian and Xenopus ANF promoters show remarkable sequence similarity, including an Nkx2-5 binding site (NKE), two GATA sites, a T-box binding site (TBE), and two SRF binding sites (SREs). Our transgenic studies show that mutation of either SRE, the TBE or the distal GATA element, strongly reduces expression from the ANF promoter. However, mutations of the NKE, the proximal GATA, or both elements together, result in relatively minor reductions in transgene expression within the myocardium. Surprisingly, mutation of these elements results in ectopic ANF promoter activity in the kidneys, facial muscles, and aortic arch artery-associated muscles, and causes persistent expression in the ventricle and outflow tract of the heart. We propose that the NKE and proximal GATA elements serve as crucial binding sites for assembly of a repressor complex that is required for atrial-specific expression of the ANF gene." @default.
• W2009572451 created "2016-06-24" @default.
• W2009572451 creator A5066353554 @default.
• W2009572451 creator A5075297399 @default.
• W2009572451 date "2003-09-01" @default.
• W2009572451 modified "2023-09-29" @default.
• W2009572451 title "Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF" @default.
• W2009572451 cites W106000010 @default.
• W2009572451 cites W1596115288 @default.
• W2009572451 cites W1955059833 @default.
• W2009572451 cites W1973431915 @default.
• W2009572451 cites W1973738440 @default.
• W2009572451 cites W1984143972 @default.
• W2009572451 cites W1989161728 @default.
• W2009572451 cites W1996068610 @default.
• W2009572451 cites W1998161518 @default.
• W2009572451 cites W2002907359 @default.
• W2009572451 cites W2004537703 @default.
• W2009572451 cites W2010064072 @default.
• W2009572451 cites W2012768791 @default.
• W2009572451 cites W2014371208 @default.
• W2009572451 cites W2015347860 @default.
• W2009572451 cites W2015396348 @default.
• W2009572451 cites W2015840464 @default.
• W2009572451 cites W2017518043 @default.
• W2009572451 cites W2018228900 @default.
• W2009572451 cites W2019621258 @default.
• W2009572451 cites W2027058574 @default.
• W2009572451 cites W2027547056 @default.
• W2009572451 cites W2036098781 @default.
• W2009572451 cites W2037215479 @default.
• W2009572451 cites W2038699628 @default.
• W2009572451 cites W2040489034 @default.
• W2009572451 cites W2040686597 @default.
• W2009572451 cites W2047916619 @default.
• W2009572451 cites W2052887240 @default.
• W2009572451 cites W2056315093 @default.
• W2009572451 cites W2060753854 @default.
• W2009572451 cites W2066423523 @default.
• W2009572451 cites W2068134261 @default.
• W2009572451 cites W2069368388 @default.
• W2009572451 cites W2076600697 @default.
• W2009572451 cites W2078475439 @default.
• W2009572451 cites W2086054284 @default.
• W2009572451 cites W2086282126 @default.
• W2009572451 cites W2089836283 @default.
• W2009572451 cites W2091866015 @default.
• W2009572451 cites W2096628719 @default.
• W2009572451 cites W2096751146 @default.
• W2009572451 cites W2097355152 @default.
• W2009572451 cites W2099883675 @default.
• W2009572451 cites W2101447839 @default.
• W2009572451 cites W2102565376 @default.
• W2009572451 cites W2106000284 @default.
• W2009572451 cites W2107688352 @default.
• W2009572451 cites W2108663844 @default.
• W2009572451 cites W2111525541 @default.
• W2009572451 cites W2116269788 @default.
• W2009572451 cites W2116583607 @default.
• W2009572451 cites W2121951679 @default.
• W2009572451 cites W2123799648 @default.
• W2009572451 cites W2127387556 @default.
• W2009572451 cites W2132859532 @default.
• W2009572451 cites W2135739418 @default.
• W2009572451 cites W2141804334 @default.
• W2009572451 cites W2147839272 @default.
• W2009572451 cites W2148557777 @default.
• W2009572451 cites W2155583879 @default.
• W2009572451 cites W2166192810 @default.
• W2009572451 cites W2186779150 @default.
• W2009572451 cites W2188737084 @default.
• W2009572451 cites W2208796000 @default.
• W2009572451 cites W2321718701 @default.
• W2009572451 doi "https://doi.org/10.1016/s0012-1606(03)00306-3" @default.
• W2009572451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12941624" @default.
• W2009572451 hasPublicationYear "2003" @default.
• W2009572451 type Work @default.
• W2009572451 sameAs 2009572451 @default.
• W2009572451 citedByCount "94" @default.
• W2009572451 countsByYear W20095724512012 @default.
• W2009572451 countsByYear W20095724512013 @default.
• W2009572451 countsByYear W20095724512014 @default.
• W2009572451 countsByYear W20095724512015 @default.
• W2009572451 countsByYear W20095724512017 @default.
• W2009572451 countsByYear W20095724512018 @default.
• W2009572451 countsByYear W20095724512019 @default.
• W2009572451 countsByYear W20095724512020 @default.
• W2009572451 countsByYear W20095724512021 @default.
• W2009572451 countsByYear W20095724512022 @default.
• W2009572451 countsByYear W20095724512023 @default.
• W2009572451 crossrefType "journal-article" @default.
• W2009572451 hasAuthorship W2009572451A5066353554 @default.
• W2009572451 hasAuthorship W2009572451A5075297399 @default.
• W2009572451 hasConcept C101762097 @default.
• W2009572451 hasConcept C102230213 @default.
• W2009572451 hasConcept C104317684 @default.
• W2009572451 hasConcept C107824862 @default.
• W2009572451 hasConcept C141035611 @default.

• next