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- W2009572885 endingPage "F378" @default.
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- W2009572885 abstract "Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases. The kidney is a kind of organ with high energy demand, rich in mitochondria. As such, mitochondrial dysfunction in the kidney plays a critical role in the pathogenesis of kidney diseases. Despite the recognized importance mitochondria play in the pathogenesis of the diseases, there is limited understanding of various aspects of mitochondrial biology. This review examines the physiology and pathophysiology of mitochondria. It begins by discussing mitochondrial structure, mitochondrial DNA, mitochondrial reactive oxygen species production, mitochondrial dynamics, and mitophagy, before turning to inherited mitochondrial cytopathies in kidneys (inherited or sporadic mitochondrial DNA or nuclear DNA mutations in genes that affect mitochondrial function). Glomerular diseases, tubular defects, and other renal diseases are then discussed. Next, acquired mitochondrial dysfunction in kidney diseases is discussed, emphasizing the role of mitochondrial dysfunction in the pathogenesis of chronic kidney disease and acute kidney injury, as their prevalence is increasing. Finally, it summarizes the possible beneficial effects of mitochondrial-targeted therapeutic agents for treatment of mitochondrial dysfunction-mediated kidney injury-genetic therapies, antioxidants, thiazolidinediones, sirtuins, and resveratrol-as mitochondrial-based drugs may offer potential treatments for renal diseases." @default.
- W2009572885 created "2016-06-24" @default.
- W2009572885 creator A5004141716 @default.
- W2009572885 creator A5028277558 @default.
- W2009572885 creator A5041999576 @default.
- W2009572885 creator A5091339708 @default.
- W2009572885 date "2014-02-15" @default.
- W2009572885 modified "2023-10-18" @default.
- W2009572885 title "Mitochondrial dysfunction in the pathophysiology of renal diseases" @default.
- W2009572885 cites W1484016032 @default.
- W2009572885 cites W1493048246 @default.
- W2009572885 cites W1524359330 @default.
- W2009572885 cites W1558823847 @default.
- W2009572885 cites W1570798354 @default.
- W2009572885 cites W1805719788 @default.
- W2009572885 cites W1884222370 @default.
- W2009572885 cites W1964914272 @default.
- W2009572885 cites W1967236260 @default.
- W2009572885 cites W1967695807 @default.
- W2009572885 cites W1972014356 @default.
- W2009572885 cites W1972556189 @default.
- W2009572885 cites W1975279812 @default.
- W2009572885 cites W1979906074 @default.
- W2009572885 cites W1981709521 @default.
- W2009572885 cites W1982087811 @default.
- W2009572885 cites W1983167541 @default.
- W2009572885 cites W1983911032 @default.
- W2009572885 cites W1986714995 @default.
- W2009572885 cites W1991064595 @default.
- W2009572885 cites W1993127259 @default.
- W2009572885 cites W1994760072 @default.
- W2009572885 cites W1995615536 @default.
- W2009572885 cites W1998245058 @default.
- W2009572885 cites W1998824052 @default.
- W2009572885 cites W1999532278 @default.
- W2009572885 cites W2000125635 @default.
- W2009572885 cites W2000671677 @default.
- W2009572885 cites W2001778733 @default.
- W2009572885 cites W2002927783 @default.
- W2009572885 cites W2003246990 @default.
- W2009572885 cites W2004709073 @default.
- W2009572885 cites W2005364039 @default.
- W2009572885 cites W2006754739 @default.
- W2009572885 cites W2014946489 @default.
- W2009572885 cites W2016196103 @default.
- W2009572885 cites W2020871623 @default.
- W2009572885 cites W2023542615 @default.
- W2009572885 cites W2024235550 @default.
- W2009572885 cites W2025046001 @default.
- W2009572885 cites W2025137145 @default.
- W2009572885 cites W2026912679 @default.
- W2009572885 cites W2028178274 @default.
- W2009572885 cites W2028543185 @default.
- W2009572885 cites W2028687515 @default.
- W2009572885 cites W2029995638 @default.
- W2009572885 cites W2031040564 @default.
- W2009572885 cites W2032434211 @default.
- W2009572885 cites W2032874629 @default.
- W2009572885 cites W2033571372 @default.
- W2009572885 cites W2034087770 @default.
- W2009572885 cites W2034381022 @default.
- W2009572885 cites W2035464681 @default.
- W2009572885 cites W2035838779 @default.
- W2009572885 cites W2036234175 @default.
- W2009572885 cites W2038011036 @default.
- W2009572885 cites W2038713498 @default.
- W2009572885 cites W2040148172 @default.
- W2009572885 cites W2043455787 @default.
- W2009572885 cites W2044138368 @default.
- W2009572885 cites W2044312018 @default.
- W2009572885 cites W2045409504 @default.
- W2009572885 cites W2046365822 @default.
- W2009572885 cites W2046751492 @default.
- W2009572885 cites W2047613950 @default.
- W2009572885 cites W2048680331 @default.
- W2009572885 cites W2049648671 @default.
- W2009572885 cites W2050889024 @default.
- W2009572885 cites W2051899676 @default.
- W2009572885 cites W2052323923 @default.
- W2009572885 cites W2055592943 @default.
- W2009572885 cites W2058238737 @default.
- W2009572885 cites W2062665180 @default.
- W2009572885 cites W2063360316 @default.
- W2009572885 cites W2066717161 @default.
- W2009572885 cites W2067463198 @default.
- W2009572885 cites W2068362864 @default.
- W2009572885 cites W2068456988 @default.
- W2009572885 cites W2068604817 @default.
- W2009572885 cites W2069519643 @default.
- W2009572885 cites W2072094974 @default.
- W2009572885 cites W2072969519 @default.
- W2009572885 cites W2074393318 @default.
- W2009572885 cites W2077972262 @default.
- W2009572885 cites W2078598822 @default.
- W2009572885 cites W2078621849 @default.
- W2009572885 cites W2081404281 @default.
- W2009572885 cites W2082393205 @default.
- W2009572885 cites W2082856250 @default.