Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009575008> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2009575008 endingPage "63" @default.
- W2009575008 startingPage "53" @default.
- W2009575008 abstract "The actions of locally applied excitatory amino acids (EAAs) on dopamine nerve terminals in the striatum of the urethane-anesthetized rat were investigated. Rapid (5 Hz)in vivoelectrochemical recording was used to measure the amplitude and duration of dopamine (DA) overflow elicited by the local application of glutamate,N-methyl-d-aspartate (NMDA), kainate, quisqualate, quinolinate anddl-α-amino-3-hydroxy-5-methylisoxazolepropionic acid. EAAs were pressure ejected into the striatum via a pipette positioned 300 ± 30 μm away from the electrochemical working electrode. Brief (5 s) applications of the EAA agonists directly elicited DA-like electrochemical signals with amplitudes averaging about 2 μM.In some instances, putative increases in ascorbic acid-like signals were detected. Repeated applications of glutamate agonists in the same brain site resulted in diminished electrochemical responses, compared to the complete reproducibility seen after repeated applications of 120 mMpotassium. Low doses of NMDA (10 μMbarrel conc), which did not cause a detectable increase in the electrochemical baseline signal, significantly potentiated (50%) potassium-evoked DA overflow. These results indicate that low levels of endogenously released glutamate may modulate overflow when DA nerve terminals are depolarized, while higher concentrations of glutamate may directly elicit increases in extracellular levels of DA and/or ascorbic acid." @default.
- W2009575008 created "2016-06-24" @default.
- W2009575008 creator A5037708891 @default.
- W2009575008 creator A5068161574 @default.
- W2009575008 date "1996-03-01" @default.
- W2009575008 modified "2023-10-10" @default.
- W2009575008 title "In VivoElectrochemical Studies of the Dynamic Effects of Locally Applied Excitatory Amino Acids in the Striatum of the Anesthetized Rat" @default.
- W2009575008 doi "https://doi.org/10.1006/exnr.1996.0046" @default.
- W2009575008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8593896" @default.
- W2009575008 hasPublicationYear "1996" @default.
- W2009575008 type Work @default.
- W2009575008 sameAs 2009575008 @default.
- W2009575008 citedByCount "11" @default.
- W2009575008 crossrefType "journal-article" @default.
- W2009575008 hasAuthorship W2009575008A5037708891 @default.
- W2009575008 hasAuthorship W2009575008A5068161574 @default.
- W2009575008 hasConcept C112592302 @default.
- W2009575008 hasConcept C12554922 @default.
- W2009575008 hasConcept C126322002 @default.
- W2009575008 hasConcept C134018914 @default.
- W2009575008 hasConcept C160268369 @default.
- W2009575008 hasConcept C169760540 @default.
- W2009575008 hasConcept C170493617 @default.
- W2009575008 hasConcept C185263204 @default.
- W2009575008 hasConcept C185592680 @default.
- W2009575008 hasConcept C189184402 @default.
- W2009575008 hasConcept C2776706248 @default.
- W2009575008 hasConcept C2777896816 @default.
- W2009575008 hasConcept C2780062018 @default.
- W2009575008 hasConcept C2910635417 @default.
- W2009575008 hasConcept C29694410 @default.
- W2009575008 hasConcept C2986274086 @default.
- W2009575008 hasConcept C31903555 @default.
- W2009575008 hasConcept C513476851 @default.
- W2009575008 hasConcept C515207424 @default.
- W2009575008 hasConcept C55493867 @default.
- W2009575008 hasConcept C61174792 @default.
- W2009575008 hasConcept C67018056 @default.
- W2009575008 hasConcept C71924100 @default.
- W2009575008 hasConcept C86803240 @default.
- W2009575008 hasConcept C98274493 @default.
- W2009575008 hasConceptScore W2009575008C112592302 @default.
- W2009575008 hasConceptScore W2009575008C12554922 @default.
- W2009575008 hasConceptScore W2009575008C126322002 @default.
- W2009575008 hasConceptScore W2009575008C134018914 @default.
- W2009575008 hasConceptScore W2009575008C160268369 @default.
- W2009575008 hasConceptScore W2009575008C169760540 @default.
- W2009575008 hasConceptScore W2009575008C170493617 @default.
- W2009575008 hasConceptScore W2009575008C185263204 @default.
- W2009575008 hasConceptScore W2009575008C185592680 @default.
- W2009575008 hasConceptScore W2009575008C189184402 @default.
- W2009575008 hasConceptScore W2009575008C2776706248 @default.
- W2009575008 hasConceptScore W2009575008C2777896816 @default.
- W2009575008 hasConceptScore W2009575008C2780062018 @default.
- W2009575008 hasConceptScore W2009575008C2910635417 @default.
- W2009575008 hasConceptScore W2009575008C29694410 @default.
- W2009575008 hasConceptScore W2009575008C2986274086 @default.
- W2009575008 hasConceptScore W2009575008C31903555 @default.
- W2009575008 hasConceptScore W2009575008C513476851 @default.
- W2009575008 hasConceptScore W2009575008C515207424 @default.
- W2009575008 hasConceptScore W2009575008C55493867 @default.
- W2009575008 hasConceptScore W2009575008C61174792 @default.
- W2009575008 hasConceptScore W2009575008C67018056 @default.
- W2009575008 hasConceptScore W2009575008C71924100 @default.
- W2009575008 hasConceptScore W2009575008C86803240 @default.
- W2009575008 hasConceptScore W2009575008C98274493 @default.
- W2009575008 hasIssue "1" @default.
- W2009575008 hasLocation W20095750081 @default.
- W2009575008 hasLocation W20095750082 @default.
- W2009575008 hasOpenAccess W2009575008 @default.
- W2009575008 hasPrimaryLocation W20095750081 @default.
- W2009575008 hasRelatedWork W1776849394 @default.
- W2009575008 hasRelatedWork W1975374033 @default.
- W2009575008 hasRelatedWork W1990197110 @default.
- W2009575008 hasRelatedWork W1992007780 @default.
- W2009575008 hasRelatedWork W2000452101 @default.
- W2009575008 hasRelatedWork W2001875278 @default.
- W2009575008 hasRelatedWork W2007192867 @default.
- W2009575008 hasRelatedWork W2018845721 @default.
- W2009575008 hasRelatedWork W2068592394 @default.
- W2009575008 hasRelatedWork W2432527344 @default.
- W2009575008 hasVolume "138" @default.
- W2009575008 isParatext "false" @default.
- W2009575008 isRetracted "false" @default.
- W2009575008 magId "2009575008" @default.
- W2009575008 workType "article" @default.