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• W2009584779 abstract "Objectives and study: Vitamin D is well known for its role in bone health, but new important roles of vitamin D are constantly identified. The aim of this study was to evaluate vitamin D status in hospitalised children living at 44° latitude, and to identify potential correlations between vitamin D levels with age, sex, and ethnia. Methods: Between 1 October 2012 and 30 April 2013, vitamin D 25(OH)3 (D3) levels in 253 inpatients were measured. We adopted two cut-off according to definitions of vitamin D deficiency and insufficiency by American Academy of Pediatrics (AAP) and The American Endocrine Society (AES) respectively: <20 and <30 ng/ml. Severe vitamin D deficiency was considered severe when D3 were <10 ng/ml, while D3 <5 ng/ml was extreme deficiency. Statistical analysis by chi square test was performed using PASW Statistics 18.0 (SPSS, Chicago, IL). Analysis was done also by three age groups: <1 year (group 1; 37 patients), 1–5 years (group 2; 121 patients) and >5 years (group 3; 94 patient). Results: Patient mean age was 5 years, 102 (59.7%) females and 151 (40.3%) males. Most patients had light skin (181, 71% caucasian + 3, 1.2% Chinese), with 26.5% (67) had dark skin: African (69.7%) and indo-pakistani (26%). Main discharge diagnosis were respiratory infections, gastro-intestinal diseases, seizures. D3 levels were skewed towards low levels and median was 17.3 ng/ml, with 25° and 75° interquartile respectively 10.7 ng/ml and 41.1 ng/ml. Analysis of total and by race prevalence is summarised in the table (Chinese children are not included due to low number).Tabled 1<30 ng/ml % (AAP) insufficiency<20 ng/ml % (AES) deficiency<10 ng/ml % severe deficiency<5 ng/ml % extreme deficiencyTotal86.960.4224.3Caucasian85.857.715.51.1African91.963.338.810.2Indo-pakistani10088.95022.2 Open table in a new tab There was no statistical difference between genders and between dark and white skin populations for the first two columns, while a significant difference was found for sever and extreme deficiency (p = 0.0001). No differences were founded between Indo-pakistani and African populations. Older children have higher risk for D3 insufficiency with a statistical difference between group 1 and group 2 and 3 (p = 0.0006 and p = 0.0001 respectively), no difference was found in D3 deficiency. Conclusion: Irrespectively from selected cut-off, the majority of hospitalised children during winter season have a high prevalence of vitamin D deficiency and insufficiency; almost 25% of children show levels below 10 ng/ml and are at risk of clinical deficiency too. Light and dark skin are both at high risk for vitamin D insufficiency, especially children above one year of age. Dark skin brings higher risk for deficiency. D3 detected levels warrant a widespread supplementation during winter season. In-patient with acute and chronic disease should be screened to treat appropriately D3 deficiency and prevent complications." @default.
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• W2009584779 date "2013-09-01" @default.
• W2009584779 modified "2023-09-26" @default.
• W2009584779 title "Winter vitamin D levels in hospitalized children living at 44° latitude" @default.
• W2009584779 doi "https://doi.org/10.1016/j.dld.2013.08.164" @default.
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