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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009584953> ?p ?o ?g. }

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• W2009584953 abstract "Krüppel-like factor 6 (KLF6) is a cancer gene (). Here, we demonstrate that KLF6 protein is rapidly degraded when apoptosis is induced via the intrinsic pathway by cisplatin, adriamycin, or UVB irradiation in multiple cell lines (HCT116, SW40, HepG2, PC3-M, Skov3, NIH-3T3, 293T, GM09706, and MEF, IMR-90). KLF6 degradation occurred in the presence or absence of p53, was associated with ubiquitination, mediated by the proteasome (half-life 16min, unstimulated), and independent of caspases and calpain. KLF6 was unchanged by apoptosis via the extrinsic/death-receptor pathway. Deregulation of KLF6 stability may alter its tumor suppressor function and/or the response of tumors to chemotherapeutics." @default.
• W2009584953 created "2016-06-24" @default.
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• W2009584953 date "2006-11-13" @default.
• W2009584953 modified "2023-10-14" @default.
• W2009584953 title "KLF6 degradation after apoptotic DNA damage" @default.
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• W2009584953 doi "https://doi.org/10.1016/j.febslet.2006.10.077" @default.
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