Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009585554> ?p ?o ?g. }
- W2009585554 endingPage "5790" @default.
- W2009585554 startingPage "5783" @default.
- W2009585554 abstract "Corticotropin releasing factor (CRF) is the primary regulator of the hypothalamus−pituitary−adrenal (HPA) axis, coordinating the endocrine, behavioral, and autonomic responses to stress. It has been postulated that small molecules that can antagonize the binding of CRF1 to its receptor may serve as a treatment for anxiety-related and/or affective disorders. Members within a series of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones, exemplified by compound 2 (IC50 = 0.70 nM), were found to be very potent antagonists of CRF1. Compound 8w showed high CRF1 receptor binding affinity and was examined further in vivo. The compound was efficacious in a defensive withdrawal model of anxiety in rats and had a long half-life and reasonable oral bioavailability in dog pharmacokinetic studies." @default.
- W2009585554 created "2016-06-24" @default.
- W2009585554 creator A5005303316 @default.
- W2009585554 creator A5006218365 @default.
- W2009585554 creator A5010145000 @default.
- W2009585554 creator A5022438790 @default.
- W2009585554 creator A5041844532 @default.
- W2009585554 creator A5044633442 @default.
- W2009585554 creator A5045701763 @default.
- W2009585554 creator A5053345252 @default.
- W2009585554 creator A5057067211 @default.
- W2009585554 creator A5057427778 @default.
- W2009585554 creator A5058124650 @default.
- W2009585554 creator A5075534723 @default.
- W2009585554 creator A5075684220 @default.
- W2009585554 creator A5082614697 @default.
- W2009585554 creator A5082849902 @default.
- W2009585554 creator A5089334960 @default.
- W2009585554 date "2004-09-29" @default.
- W2009585554 modified "2023-10-18" @default.
- W2009585554 title "Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1<i>H</i>-pyrido[2,3-<i>b</i>]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists" @default.
- W2009585554 cites W1965874521 @default.
- W2009585554 cites W1967964534 @default.
- W2009585554 cites W1973994559 @default.
- W2009585554 cites W1974253960 @default.
- W2009585554 cites W1987699658 @default.
- W2009585554 cites W1987716995 @default.
- W2009585554 cites W1999281381 @default.
- W2009585554 cites W2008690448 @default.
- W2009585554 cites W2031767608 @default.
- W2009585554 cites W2048417345 @default.
- W2009585554 cites W2079718339 @default.
- W2009585554 cites W2089673716 @default.
- W2009585554 cites W2095036452 @default.
- W2009585554 cites W2095317731 @default.
- W2009585554 cites W2107337535 @default.
- W2009585554 cites W2334353699 @default.
- W2009585554 cites W2952573240 @default.
- W2009585554 cites W4315563345 @default.
- W2009585554 cites W4376848280 @default.
- W2009585554 doi "https://doi.org/10.1021/jm049737f" @default.
- W2009585554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15509177" @default.
- W2009585554 hasPublicationYear "2004" @default.
- W2009585554 type Work @default.
- W2009585554 sameAs 2009585554 @default.
- W2009585554 citedByCount "14" @default.
- W2009585554 countsByYear W20095855542012 @default.
- W2009585554 countsByYear W20095855542013 @default.
- W2009585554 countsByYear W20095855542015 @default.
- W2009585554 countsByYear W20095855542017 @default.
- W2009585554 countsByYear W20095855542020 @default.
- W2009585554 crossrefType "journal-article" @default.
- W2009585554 hasAuthorship W2009585554A5005303316 @default.
- W2009585554 hasAuthorship W2009585554A5006218365 @default.
- W2009585554 hasAuthorship W2009585554A5010145000 @default.
- W2009585554 hasAuthorship W2009585554A5022438790 @default.
- W2009585554 hasAuthorship W2009585554A5041844532 @default.
- W2009585554 hasAuthorship W2009585554A5044633442 @default.
- W2009585554 hasAuthorship W2009585554A5045701763 @default.
- W2009585554 hasAuthorship W2009585554A5053345252 @default.
- W2009585554 hasAuthorship W2009585554A5057067211 @default.
- W2009585554 hasAuthorship W2009585554A5057427778 @default.
- W2009585554 hasAuthorship W2009585554A5058124650 @default.
- W2009585554 hasAuthorship W2009585554A5075534723 @default.
- W2009585554 hasAuthorship W2009585554A5075684220 @default.
- W2009585554 hasAuthorship W2009585554A5082614697 @default.
- W2009585554 hasAuthorship W2009585554A5082849902 @default.
- W2009585554 hasAuthorship W2009585554A5089334960 @default.
- W2009585554 hasConcept C112705442 @default.
- W2009585554 hasConcept C114373084 @default.
- W2009585554 hasConcept C126322002 @default.
- W2009585554 hasConcept C134018914 @default.
- W2009585554 hasConcept C150903083 @default.
- W2009585554 hasConcept C170493617 @default.
- W2009585554 hasConcept C181389837 @default.
- W2009585554 hasConcept C185592680 @default.
- W2009585554 hasConcept C193042331 @default.
- W2009585554 hasConcept C202751555 @default.
- W2009585554 hasConcept C207001950 @default.
- W2009585554 hasConcept C2777752112 @default.
- W2009585554 hasConcept C55493867 @default.
- W2009585554 hasConcept C71240020 @default.
- W2009585554 hasConcept C71924100 @default.
- W2009585554 hasConcept C86803240 @default.
- W2009585554 hasConcept C98274493 @default.
- W2009585554 hasConceptScore W2009585554C112705442 @default.
- W2009585554 hasConceptScore W2009585554C114373084 @default.
- W2009585554 hasConceptScore W2009585554C126322002 @default.
- W2009585554 hasConceptScore W2009585554C134018914 @default.
- W2009585554 hasConceptScore W2009585554C150903083 @default.
- W2009585554 hasConceptScore W2009585554C170493617 @default.
- W2009585554 hasConceptScore W2009585554C181389837 @default.
- W2009585554 hasConceptScore W2009585554C185592680 @default.
- W2009585554 hasConceptScore W2009585554C193042331 @default.
- W2009585554 hasConceptScore W2009585554C202751555 @default.
- W2009585554 hasConceptScore W2009585554C207001950 @default.
- W2009585554 hasConceptScore W2009585554C2777752112 @default.
- W2009585554 hasConceptScore W2009585554C55493867 @default.