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• W2009588836 endingPage "348" @default.
• W2009588836 startingPage "335" @default.
• W2009588836 abstract "Transcription factors/activators are a group of proteins that bind to specific consensus sequences (cis elements) in the promoter regions of downstream target/effector genes and transactivate or repress effector gene expression. The up-or downregulation of effector genes will ultimately lead to many biological changes such as proliferation, growth suppression, differentiation, or senescence. Transcription factors are subject to transcriptional and posttranslational regulation. This review will focus on the redox (reduction/oxidation) regulation of transcription factors/activators with emphasis on p53, AP-1, and NF-KB. The redox regulation of transcriptional activators occurs through highly conserved cysteine residues in the DNA binding domains of these proteins. In vitro studies have shown that reducing environments increase, while oxidizing conditions inhibit sequence-specific DNA binding of these transcriptional activators. When intact cells have been used for study, a more complex regulation has been observed. Reduction/oxidation can either up-or downregulate DNA binding and/or transactivation activities in transcriptional activator-dependent as well as cell type-dependent manners. In general, reductants decrease p53 and NF-KB activities but dramatically activate AP-1 activity. Oxidants, on the other hand, greatly activate NF-KB activity. Furthermore, redox-induced biochemical alterations sometimes lead to change in the biological functions of these proteins. Therefore, differential regulation of these transcriptional activators, which in turn, regulate many target/ effector genes, may provide an additional mechanism by which small antioxidant molecules play protective roles in anticancer and antiaging processes. Better understanding of the mechanism of redox regulation, particularly in vivo, will have an important impact on drug discovery for chemoprevention and therapy of human diseases such as cancer." @default.
• W2009588836 created "2016-06-24" @default.
• W2009588836 creator A5051826848 @default.
• W2009588836 creator A5066626887 @default.
• W2009588836 date "1996-01-01" @default.
• W2009588836 modified "2023-10-16" @default.
• W2009588836 title "Redox regulation of transcriptional activators" @default.
• W2009588836 cites W126627744 @default.
• W2009588836 cites W1484205189 @default.
• W2009588836 cites W1501442799 @default.
• W2009588836 cites W1507168437 @default.
• W2009588836 cites W1516457342 @default.
• W2009588836 cites W1516945930 @default.
• W2009588836 cites W1520976404 @default.
• W2009588836 cites W1530152501 @default.
• W2009588836 cites W1532066573 @default.
• W2009588836 cites W1555938743 @default.
• W2009588836 cites W1561376991 @default.
• W2009588836 cites W1568529372 @default.
• W2009588836 cites W1577403013 @default.
• W2009588836 cites W1581477122 @default.
• W2009588836 cites W1583104418 @default.
• W2009588836 cites W1597702906 @default.
• W2009588836 cites W1600605923 @default.
• W2009588836 cites W16019424 @default.
• W2009588836 cites W1603904020 @default.
• W2009588836 cites W1815879748 @default.
• W2009588836 cites W1851224896 @default.
• W2009588836 cites W1932728046 @default.
• W2009588836 cites W1948721092 @default.
• W2009588836 cites W1949973946 @default.
• W2009588836 cites W1964960571 @default.
• W2009588836 cites W1971833357 @default.
• W2009588836 cites W1973328612 @default.
• W2009588836 cites W1980730214 @default.
• W2009588836 cites W1980909735 @default.
• W2009588836 cites W1982265633 @default.
• W2009588836 cites W1983839215 @default.
• W2009588836 cites W1984151035 @default.
• W2009588836 cites W1994975139 @default.
• W2009588836 cites W1995266526 @default.
• W2009588836 cites W1995508379 @default.
• W2009588836 cites W1995856480 @default.
• W2009588836 cites W1996176524 @default.
• W2009588836 cites W1999275729 @default.
• W2009588836 cites W2004442904 @default.
• W2009588836 cites W2005546492 @default.
• W2009588836 cites W2008035030 @default.
• W2009588836 cites W2010416554 @default.
• W2009588836 cites W2012053348 @default.
• W2009588836 cites W2012353929 @default.
• W2009588836 cites W2013013150 @default.
• W2009588836 cites W2015519364 @default.
• W2009588836 cites W2024267687 @default.
• W2009588836 cites W2026959257 @default.
• W2009588836 cites W2027569621 @default.
• W2009588836 cites W2035161742 @default.
• W2009588836 cites W2036351375 @default.
• W2009588836 cites W2040098277 @default.
• W2009588836 cites W2042260090 @default.
• W2009588836 cites W2042316019 @default.
• W2009588836 cites W2042830363 @default.
• W2009588836 cites W2048327622 @default.
• W2009588836 cites W2048840807 @default.
• W2009588836 cites W2052232305 @default.
• W2009588836 cites W2055289917 @default.
• W2009588836 cites W2057093252 @default.
• W2009588836 cites W2059851697 @default.
• W2009588836 cites W2060634635 @default.
• W2009588836 cites W2061903251 @default.
• W2009588836 cites W2064000861 @default.
• W2009588836 cites W2064345521 @default.
• W2009588836 cites W2066384004 @default.
• W2009588836 cites W2068001141 @default.
• W2009588836 cites W2068571186 @default.
• W2009588836 cites W2070693959 @default.
• W2009588836 cites W2074222004 @default.
• W2009588836 cites W2076753287 @default.
• W2009588836 cites W2081839629 @default.
• W2009588836 cites W2087284330 @default.
• W2009588836 cites W2089126365 @default.
• W2009588836 cites W2090025028 @default.
• W2009588836 cites W2091548699 @default.
• W2009588836 cites W2096276671 @default.
• W2009588836 cites W2103339981 @default.
• W2009588836 cites W2110591890 @default.
• W2009588836 cites W2119603369 @default.
• W2009588836 cites W2128583894 @default.
• W2009588836 cites W2145337751 @default.
• W2009588836 cites W2148069086 @default.
• W2009588836 cites W2149973032 @default.
• W2009588836 cites W2150627157 @default.
• W2009588836 cites W2151160119 @default.
• W2009588836 cites W2151818957 @default.
• W2009588836 cites W2151892297 @default.
• W2009588836 cites W2159567970 @default.
• W2009588836 cites W2161222674 @default.
• W2009588836 cites W2167604659 @default.

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