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• W2009589033 abstract "The MRN complex consists of the two evolutionarily conserved components Mre11 and Rad50 and the third less-conserved component Nbs1/Xrs2 [1D'Amours D. Jackson S.P. The Mre11 complex at the crossroads of DNA repair and checkpoint signalling.Nat. Rev. Mol. Cell Biol. 2002; 3: 317-327Crossref PubMed Scopus (693) Google Scholar, 2Hopfner K.P. Putnam C.D. Tainer J.A. DNA double-strand break repair from head to tail.Curr. Opin. Struct. Biol. 2002; 12: 115-122Crossref PubMed Scopus (116) Google Scholar]. This complex mediates telomere maintenance in addition to a variety of functions in response to DNA double-strand breaks, including homologous recombination, nonhomologous end joining (NHEJ), and activation of DNA damage checkpoints. Mutations in the Mre11 gene cause the human ataxia-telangiectasia-like disorder (ATDL) [1D'Amours D. Jackson S.P. The Mre11 complex at the crossroads of DNA repair and checkpoint signalling.Nat. Rev. Mol. Cell Biol. 2002; 3: 317-327Crossref PubMed Scopus (693) Google Scholar, 2Hopfner K.P. Putnam C.D. Tainer J.A. DNA double-strand break repair from head to tail.Curr. Opin. Struct. Biol. 2002; 12: 115-122Crossref PubMed Scopus (116) Google Scholar]. Here, we show that null mutations in the Drosophila mre11 and rad50 genes cause both telomeric fusion and chromosome breakage. Moreover, we demonstrate that these mutations are in the same epistasis group required for telomere capping and mitotic chromosome integrity. Using an antibody against Rad50, we show that this protein is uniformly distributed along mitotic chromosomes, and that Rad50 is unstable in the absence of its binding partner Mre11. To define the roles of rad50 and mre11 in telomere protection, mutant chromosome preparations were immunostained for both HP1 and HOAP, two proteins that protect Drosophila telomeres from fusion [3Fanti L. Giovinazzo G. Berloco M. Pimpinelli S. The heterochromatin protein 1 prevents telomere fusions in Drosophila.Mol. Cell. 1998; 2: 527-538Abstract Full Text Full Text PDF PubMed Scopus (241) Google Scholar, 4Cenci G. Siriaco G. Raffa G.D. Kellum R. Gatti M. The Drosophila HOAP protein is required for telomere capping.Nat. Cell Biol. 2003; 5: 82-84Crossref PubMed Scopus (129) Google Scholar]. Cytological analysis revealed that mutations in rad50 and mre11 drastically reduce accumulation of HOAP and HP1 at telomeres. This suggests that the MRN complex protects Drosophila telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends." @default.
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• W2009589033 date "2004-08-01" @default.
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• W2009589033 title "The Drosophila Mre11/Rad50 Complex Is Required to Prevent Both Telomeric Fusion and Chromosome Breakage" @default.
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• W2009589033 doi "https://doi.org/10.1016/j.cub.2004.07.019" @default.
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