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- W2009591063 abstract "Chemotherapy for childhood acute lymphoblastic leukemia may cause severe immune damage. The lymphocyte compartment of 140 patients during and after a new strongly reduced (standard risk (SR), n = 43) and intensive chemotherapy regimen (medium risk (MR), n = 97) was studied between 2006 and 2009. Transitional and naive B cells and IgG + /A + , IgM + and IgM only memory B cells were significantly reduced during chemotherapy; significantly more in MR group. One year after treatment CD27 + IgG + /A + , IgM + and IgM only memory B cells had still not fully recovered, but this was not confined to the MR group. The T cell compartment was less but also significantly affected during chemotherapy and recovered to normal levels. In the MR group, NK cells had not fully recovered to normal levels 1 year after treatment. Thus, intensive chemotherapy regimens cause severe, mainly B cell memory damage that persists even 1 year after treatment." @default.
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- W2009591063 date "2011-04-01" @default.
- W2009591063 modified "2023-10-14" @default.
- W2009591063 title "Reduced versus intensive chemotherapy for childhood acute lymphoblastic leukemia: Impact on lymphocyte compartment composition" @default.
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- W2009591063 doi "https://doi.org/10.1016/j.leukres.2010.10.005" @default.
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