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- W2009592092 abstract "A high-performance liquid chromatographic method for indirect determination of enalapril in human plasma, was developed and validated. An exogenous angiotensin converting enzyme after drug inhibition was determined by reacting with hippuryl-histidyl-leucine to produce hippuric acid (HA) which was inversely proportional to the amount of enalaprilat in plasma. The HPLC was carried out on a Lichrosphere 60RP-select B, C18, 5 microm (125 mm x 4.0 mm i.d.) column at flow rate of 1.0 ml/min. The analysis time per injection was within 6.5 min. The lowest concentration of enalaprilat to be quantitated was 3.0 ng/ml with the acceptable accuracy and precision. This successfully developed method was practically and accurately used for pharmacokinetics and bioequivalent study of enalapril." @default.
- W2009592092 created "2016-06-24" @default.
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- W2009592092 date "2005-04-01" @default.
- W2009592092 modified "2023-10-16" @default.
- W2009592092 title "High-performance liquid chromatographic determination of enalapril in human plasma by enzyme kinetic analytical method" @default.
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- W2009592092 doi "https://doi.org/10.1016/j.jpba.2004.10.053" @default.
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