FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009594554> ?p ?o ?g. }

• W2009594554 endingPage "286" @default.
• W2009594554 startingPage "275" @default.
• W2009594554 abstract "The pituitary-adrenocortical axis plays a complex role in the regulation of the levels of enzymes of the catecholamine biosynthetic pathway. In this report we have explored molecular mechanisms of these regulations, by examining the effects of hypophysectomy (HPX) and dexamethasone (DEX) on tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA levels in the adrenal medulla (AM) and superior cervical ganglia (SCG). Three weeks after hypophysectomy weights (-48%), total RNA (-49%), and DNA (-22%) contents in AM were significantly reduced, when compared to sham-operated animals (SO). In SCG decreases in weight (-23%) and in the ratio of RNA/DNA (-25%) were also found. TH mRNA contents paralleled decreases in total RNA levels and no significant change in the relative abundance of TH mRNA was found. When HPX rats were injected for 5 days with DEX (1 mg/kg, i.p.), TH mRNA levels in the SCG (+51%) and in the AM (+74%) were significantly increased when compared to saline-treated HPX animals. DEX given to SO rats increased TH mRNA in SCG (+49%); a 27% increase in TH mRNA in the AM was also observed. The relative abundance of PNMT mRNA in the AM was reduced after hypophysectomy (-64%). This decrease was completely reversed by DEX. In contrast, DEX did not affect PNMT mRNA levels in the AM of SO rats. PNMT mRNA was not detected in SCG of saline- or DEX-treated rats. In conclusion, our findings suggest that the pituitary-adrenocortical axis is involved in the regulation of the steady-state levels of TH and PNMT mRNAs. This regulation involves: (1) induction of TH mRNA contents in AM and SCG by increased plasma glucocorticoid levels; and (2) maintenance of the steady-state levels of PNMT mRNA in AM by glucocorticoid-dependent mechanisms." @default.
• W2009594554 created "2016-06-24" @default.
• W2009594554 creator A5032753064 @default.
• W2009594554 creator A5067529164 @default.
• W2009594554 creator A5071852918 @default.
• W2009594554 creator A5081391220 @default.
• W2009594554 creator A5086500937 @default.
• W2009594554 date "1988-06-01" @default.
• W2009594554 modified "2023-10-18" @default.
• W2009594554 title "Regulation of tyrosine hydroxylase and phenylethanolamine N-methyltransferase mRNA levels in the sympathoadrenal system by the pituitary-adrenocortical axis" @default.
• W2009594554 cites W1566125473 @default.
• W2009594554 cites W1571575178 @default.
• W2009594554 cites W1775749144 @default.
• W2009594554 cites W1986728536 @default.
• W2009594554 cites W1994604517 @default.
• W2009594554 cites W2007259597 @default.
• W2009594554 cites W2018532868 @default.
• W2009594554 cites W2019341113 @default.
• W2009594554 cites W2021080605 @default.
• W2009594554 cites W2024599586 @default.
• W2009594554 cites W2031753737 @default.
• W2009594554 cites W2033396324 @default.
• W2009594554 cites W2039175918 @default.
• W2009594554 cites W2041032747 @default.
• W2009594554 cites W2043791744 @default.
• W2009594554 cites W2046575894 @default.
• W2009594554 cites W2059288635 @default.
• W2009594554 cites W2065888432 @default.
• W2009594554 cites W2069504903 @default.
• W2009594554 cites W2073726261 @default.
• W2009594554 cites W2080670130 @default.
• W2009594554 cites W2083256719 @default.
• W2009594554 cites W2117080819 @default.
• W2009594554 cites W2144476092 @default.
• W2009594554 cites W2153562862 @default.
• W2009594554 cites W2317697683 @default.
• W2009594554 cites W2414838515 @default.
• W2009594554 doi "https://doi.org/10.1016/0169-328x(88)90050-2" @default.
• W2009594554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2900043" @default.
• W2009594554 hasPublicationYear "1988" @default.
• W2009594554 type Work @default.
• W2009594554 sameAs 2009594554 @default.
• W2009594554 citedByCount "52" @default.
• W2009594554 countsByYear W20095945542012 @default.
• W2009594554 countsByYear W20095945542013 @default.
• W2009594554 countsByYear W20095945542014 @default.
• W2009594554 countsByYear W20095945542015 @default.
• W2009594554 countsByYear W20095945542016 @default.
• W2009594554 crossrefType "journal-article" @default.
• W2009594554 hasAuthorship W2009594554A5032753064 @default.
• W2009594554 hasAuthorship W2009594554A5067529164 @default.
• W2009594554 hasAuthorship W2009594554A5071852918 @default.
• W2009594554 hasAuthorship W2009594554A5081391220 @default.
• W2009594554 hasAuthorship W2009594554A5086500937 @default.
• W2009594554 hasConcept C104317684 @default.
• W2009594554 hasConcept C105580179 @default.
• W2009594554 hasConcept C126322002 @default.
• W2009594554 hasConcept C134018914 @default.
• W2009594554 hasConcept C159167319 @default.
• W2009594554 hasConcept C2775894120 @default.
• W2009594554 hasConcept C2776804559 @default.
• W2009594554 hasConcept C2777597313 @default.
• W2009594554 hasConcept C2777658017 @default.
• W2009594554 hasConcept C2779546955 @default.
• W2009594554 hasConcept C2780104272 @default.
• W2009594554 hasConcept C2780401358 @default.
• W2009594554 hasConcept C2780841215 @default.
• W2009594554 hasConcept C33288867 @default.
• W2009594554 hasConcept C513476851 @default.
• W2009594554 hasConcept C552990157 @default.
• W2009594554 hasConcept C55493867 @default.
• W2009594554 hasConcept C71315377 @default.
• W2009594554 hasConcept C71924100 @default.
• W2009594554 hasConcept C86803240 @default.
• W2009594554 hasConcept C91965660 @default.
• W2009594554 hasConceptScore W2009594554C104317684 @default.
• W2009594554 hasConceptScore W2009594554C105580179 @default.
• W2009594554 hasConceptScore W2009594554C126322002 @default.
• W2009594554 hasConceptScore W2009594554C134018914 @default.
• W2009594554 hasConceptScore W2009594554C159167319 @default.
• W2009594554 hasConceptScore W2009594554C2775894120 @default.
• W2009594554 hasConceptScore W2009594554C2776804559 @default.
• W2009594554 hasConceptScore W2009594554C2777597313 @default.
• W2009594554 hasConceptScore W2009594554C2777658017 @default.
• W2009594554 hasConceptScore W2009594554C2779546955 @default.
• W2009594554 hasConceptScore W2009594554C2780104272 @default.
• W2009594554 hasConceptScore W2009594554C2780401358 @default.
• W2009594554 hasConceptScore W2009594554C2780841215 @default.
• W2009594554 hasConceptScore W2009594554C33288867 @default.
• W2009594554 hasConceptScore W2009594554C513476851 @default.
• W2009594554 hasConceptScore W2009594554C552990157 @default.
• W2009594554 hasConceptScore W2009594554C55493867 @default.
• W2009594554 hasConceptScore W2009594554C71315377 @default.
• W2009594554 hasConceptScore W2009594554C71924100 @default.
• W2009594554 hasConceptScore W2009594554C86803240 @default.
• W2009594554 hasConceptScore W2009594554C91965660 @default.
• W2009594554 hasIssue "3" @default.
• W2009594554 hasLocation W20095945541 @default.

• next