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• W2009595511 abstract "G4 DNA motifs, which can form stable secondary structures called G-quadruplexes, are ubiquitous in eukaryotic genomes, and have been shown to cause genomic instability. Specialized helicases that unwind G-quadruplexes in vitro have been identified, and they have been shown to prevent genetic instability in vivo. In the absence of these helicases, G-quadruplexes can persist and cause replication fork stalling and collapse. Translesion synthesis (TLS) and homologous recombination (HR) have been proposed to play a role in the repair of this damage, but recently it was found in the nematode Caenorhabditis elegans that G4-induced genome alterations are generated by an error-prone repair mechanism that is dependent on the A-family polymerase Theta (Pol θ). Current data point towards a scenario where DNA replication blocked at G-quadruplexes causes DNA double strand breaks (DSBs), and where the choice of repair pathway that can act on these breaks dictates the nature of genomic alterations that are observed in various organisms." @default.
• W2009595511 created "2016-06-24" @default.
• W2009595511 creator A5030191931 @default.
• W2009595511 creator A5060457182 @default.
• W2009595511 date "2014-11-01" @default.
• W2009595511 modified "2023-09-23" @default.
• W2009595511 title "The repair of G-quadruplex-induced DNA damage" @default.
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• W2009595511 doi "https://doi.org/10.1016/j.yexcr.2014.08.038" @default.
• W2009595511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25193076" @default.
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