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- W2009599018 abstract "RhoB is the only member of the Rho subfamily of small GTPases, which is classified as an immediate early gene product. RhoB is up-regulated in response to growth factors as well as cytotoxic and genotoxic agents. Clostridial glucosylating toxins have been reported to evoke pronounced RhoB expression, based on the inactivation of Rho/Ras proteins. In this study, we report on a long lasting expression of RhoB in cultured cells upon activation of Rho proteins by the cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli. The observations of this study highlight a new pathway involving Rac1, which positively regulates the activity of the rhoB promoter and RhoB expression. Conversely, the isomeric cytotoxic necrotizing factor from Yersinia pseudotuberculosis (CNFy) drives GTP-loading of basal RhoB but fails to cause activation of the rhoB promoter and thus its expression. CNF1 inhibits cytokinesis and induces the formation of bi-nucleated (tetraploid) cells. Upon long term treatment with CNF1, RhoB(-/-) mouse embryonic fibroblasts (MEFs) exhibit DNA fragmentation, phosphatidylserine exposure, and loss of membrane integrity, while RhoB(+/-) MEFs persist as bi-nucleated (tetraploid) cells without any signs of cell death. In conclusion, the cytoprotective RhoB response is not only evoked by bacterial protein toxins inactivating Rho/Ras proteins but also by the Rac1-activating toxin CNF1." @default.
- W2009599018 created "2016-06-24" @default.
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- W2009599018 date "2013-08-01" @default.
- W2009599018 modified "2023-10-02" @default.
- W2009599018 title "Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1" @default.
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- W2009599018 cites W1974653642 @default.
- W2009599018 cites W1975471201 @default.
- W2009599018 cites W1982061117 @default.
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- W2009599018 cites W1989983318 @default.
- W2009599018 cites W1992108472 @default.
- W2009599018 cites W1994901157 @default.
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- W2009599018 cites W2024230488 @default.
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- W2009599018 cites W2026029310 @default.
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- W2009599018 doi "https://doi.org/10.1016/j.biocel.2013.05.020" @default.
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