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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009607549> ?p ?o ?g. }

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• W2009607549 abstract "The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy for viral infections and tumors in animal models. The application of this approach to human disease would require the isolation and in vitro expansion of human antigen-specific T cells and evidence that such T cells persist and function in vivo after transfer. Cytomegalovirus-specific CD8++ cytotoxic T cell (CTL) clones could be isolated from bone marrow donors, propagated in vitro, and adoptively transferred to immunodeficient bone marrow transplant recipients. No toxicity developed and the clones provided persistent reconstitution of CD8++ cytomegalovirus-specific CTL responses." @default.
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• W2009607549 date "1992-07-10" @default.
• W2009607549 modified "2023-10-16" @default.
• W2009607549 title "Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones" @default.
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• W2009607549 doi "https://doi.org/10.1126/science.1352912" @default.
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