FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009609368> ?p ?o ?g. }

• W2009609368 endingPage "634" @default.
• W2009609368 startingPage "628" @default.
• W2009609368 abstract "Recently, we discovered a T(-786)-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene that is associated with coronary spasm. The precise mechanism(s) of myocardial infarction (MI), especially without coronary organic stenosis, has not been elucidated, but it seems possible that coronary spasm plays a key role in the mechanism. In this study, we examined the frequency with which the T(-786)-->C mutation occurred in 359 patients with MI who were compared with 195 controls. In the MI group, the frequency of C/C, C/T, and T/T genotypes was 1%, 22%, and 77%, respectively. In the control group, the frequency of C/C, C/T, and T/T genotypes were 0%, 8%, and 92%, respectively. The frequency of the C allele was significantly higher in the MI group than in the control group (p < 0.001). In the MI group, 30 of 359 patients (8%) with MI had no stenosed vessels angiographically, 158 (44%) had 1 stenosed vessel, 80 (22%) had 2 stenosed vessels, and 91 (25%) exhibited 3 stenosed vessels. Total and low-density lipoprotein cholesterol levels and the incidence of diabetes mellitus increased as the number of stenosed vessels increased (p < 0.01, respectively). The frequency of the T(-786)-->C mutation was significantly higher in MI patients with no stenosed vessels (50%) than in those with stenosed vessels (p < 0.003). In conclusion, the T(-786)-->C mutation was strongly associated with MI, especially without coronary arterial stenosis, in Japanese patients. The association may be due to the impaired effects of nitric oxide in the cardiovascular system." @default.
• W2009609368 created "2016-06-24" @default.
• W2009609368 creator A5001368432 @default.
• W2009609368 creator A5012233468 @default.
• W2009609368 creator A5020090012 @default.
• W2009609368 creator A5033980070 @default.
• W2009609368 creator A5049895325 @default.
• W2009609368 creator A5055474625 @default.
• W2009609368 creator A5064352051 @default.
• W2009609368 creator A5066956159 @default.
• W2009609368 creator A5074060371 @default.
• W2009609368 creator A5075495420 @default.
• W2009609368 creator A5080245088 @default.
• W2009609368 creator A5085879794 @default.
• W2009609368 creator A5087424396 @default.
• W2009609368 creator A5091430660 @default.
• W2009609368 date "2000-09-01" @default.
• W2009609368 modified "2023-10-02" @default.
• W2009609368 title "T−786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis" @default.
• W2009609368 cites W1965816941 @default.
• W2009609368 cites W1971507375 @default.
• W2009609368 cites W1984272587 @default.
• W2009609368 cites W1992000409 @default.
• W2009609368 cites W1996465975 @default.
• W2009609368 cites W2013023382 @default.
• W2009609368 cites W2027433622 @default.
• W2009609368 cites W2033994114 @default.
• W2009609368 cites W2035303091 @default.
• W2009609368 cites W2076795933 @default.
• W2009609368 cites W2088667193 @default.
• W2009609368 cites W2147534219 @default.
• W2009609368 cites W2311246384 @default.
• W2009609368 cites W4365787936 @default.
• W2009609368 doi "https://doi.org/10.1016/s0002-9149(00)01041-9" @default.
• W2009609368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10980213" @default.
• W2009609368 hasPublicationYear "2000" @default.
• W2009609368 type Work @default.
• W2009609368 sameAs 2009609368 @default.
• W2009609368 citedByCount "135" @default.
• W2009609368 countsByYear W20096093682012 @default.
• W2009609368 countsByYear W20096093682013 @default.
• W2009609368 countsByYear W20096093682014 @default.
• W2009609368 countsByYear W20096093682015 @default.
• W2009609368 countsByYear W20096093682016 @default.
• W2009609368 countsByYear W20096093682017 @default.
• W2009609368 countsByYear W20096093682018 @default.
• W2009609368 countsByYear W20096093682019 @default.
• W2009609368 countsByYear W20096093682020 @default.
• W2009609368 countsByYear W20096093682021 @default.
• W2009609368 countsByYear W20096093682022 @default.
• W2009609368 countsByYear W20096093682023 @default.
• W2009609368 crossrefType "journal-article" @default.
• W2009609368 hasAuthorship W2009609368A5001368432 @default.
• W2009609368 hasAuthorship W2009609368A5012233468 @default.
• W2009609368 hasAuthorship W2009609368A5020090012 @default.
• W2009609368 hasAuthorship W2009609368A5033980070 @default.
• W2009609368 hasAuthorship W2009609368A5049895325 @default.
• W2009609368 hasAuthorship W2009609368A5055474625 @default.
• W2009609368 hasAuthorship W2009609368A5064352051 @default.
• W2009609368 hasAuthorship W2009609368A5066956159 @default.
• W2009609368 hasAuthorship W2009609368A5074060371 @default.
• W2009609368 hasAuthorship W2009609368A5075495420 @default.
• W2009609368 hasAuthorship W2009609368A5080245088 @default.
• W2009609368 hasAuthorship W2009609368A5085879794 @default.
• W2009609368 hasAuthorship W2009609368A5087424396 @default.
• W2009609368 hasAuthorship W2009609368A5091430660 @default.
• W2009609368 hasConcept C104317684 @default.
• W2009609368 hasConcept C126322002 @default.
• W2009609368 hasConcept C135763542 @default.
• W2009609368 hasConcept C164705383 @default.
• W2009609368 hasConcept C2776820930 @default.
• W2009609368 hasConcept C2777622882 @default.
• W2009609368 hasConcept C2778742706 @default.
• W2009609368 hasConcept C2780007028 @default.
• W2009609368 hasConcept C2780972559 @default.
• W2009609368 hasConcept C500558357 @default.
• W2009609368 hasConcept C519581460 @default.
• W2009609368 hasConcept C54355233 @default.
• W2009609368 hasConcept C71924100 @default.
• W2009609368 hasConcept C86803240 @default.
• W2009609368 hasConceptScore W2009609368C104317684 @default.
• W2009609368 hasConceptScore W2009609368C126322002 @default.
• W2009609368 hasConceptScore W2009609368C135763542 @default.
• W2009609368 hasConceptScore W2009609368C164705383 @default.
• W2009609368 hasConceptScore W2009609368C2776820930 @default.
• W2009609368 hasConceptScore W2009609368C2777622882 @default.
• W2009609368 hasConceptScore W2009609368C2778742706 @default.
• W2009609368 hasConceptScore W2009609368C2780007028 @default.
• W2009609368 hasConceptScore W2009609368C2780972559 @default.
• W2009609368 hasConceptScore W2009609368C500558357 @default.
• W2009609368 hasConceptScore W2009609368C519581460 @default.
• W2009609368 hasConceptScore W2009609368C54355233 @default.
• W2009609368 hasConceptScore W2009609368C71924100 @default.
• W2009609368 hasConceptScore W2009609368C86803240 @default.
• W2009609368 hasFunder F4320310760 @default.
• W2009609368 hasFunder F4320320912 @default.
• W2009609368 hasFunder F4320322034 @default.
• W2009609368 hasFunder F4320322555 @default.

• next