FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009610048> ?p ?o ?g. }

• W2009610048 endingPage "2622" @default.
• W2009610048 startingPage "2616" @default.
• W2009610048 abstract "Lamina propria (LP) T cells respond poorly to a proliferative stimulus delivered via TCR/CD3 pathway, but retain considerable ability to respond to a stimulus delivered via CD2 costimulatory or accessory pathway. In the present study, we showed first that unstimulated LP T cells, as compared to unstimulated peripheral blood (PB) T cells, exhibit an increased level of apoptosis which is further increased following CD2 pathway stimulation, but not following via TCR/CD3 pathway stimulation. We next showed that IL-2 had a sparing effect on apoptosis of unstimulated LP T cells in that IL-2 decreased and anti-IL-2 increased apoptosis of these cells; in contrast, IL-2 had no effect on apoptosis of CD2-pathway stimulated cells. Finally, we showed that increased apoptosis of LP T cells induced by CD2-pathway stimulation is inhibited when Fas antigen is blocked by a nonstimulatory anti-Fas antibody. These studies suggest that LP T cells are characterized by increased susceptibility to Fas-mediated apoptosis most due to a downstream change in the Fas signaling pathway. Given that IFN-gamma secretion is significantly increased in LP T cells in which apoptosis is inhibited, this feature of LP T cells may represent a mechanism of regulating detrimental immune responses in the mucosal environment." @default.
• W2009610048 created "2016-06-24" @default.
• W2009610048 creator A5008050913 @default.
• W2009610048 creator A5009705533 @default.
• W2009610048 creator A5042097944 @default.
• W2009610048 creator A5053370481 @default.
• W2009610048 creator A5076073255 @default.
• W2009610048 creator A5077194201 @default.
• W2009610048 date "1996-12-01" @default.
• W2009610048 modified "2023-10-03" @default.
• W2009610048 title "Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis." @default.
• W2009610048 cites W1516581843 @default.
• W2009610048 cites W1539984014 @default.
• W2009610048 cites W1576055832 @default.
• W2009610048 cites W1594989289 @default.
• W2009610048 cites W1604581840 @default.
• W2009610048 cites W1607475594 @default.
• W2009610048 cites W1785380284 @default.
• W2009610048 cites W1857741692 @default.
• W2009610048 cites W1946093640 @default.
• W2009610048 cites W1965385111 @default.
• W2009610048 cites W2002507218 @default.
• W2009610048 cites W2002733542 @default.
• W2009610048 cites W2003801599 @default.
• W2009610048 cites W2004645606 @default.
• W2009610048 cites W2011585638 @default.
• W2009610048 cites W2013052118 @default.
• W2009610048 cites W2017628675 @default.
• W2009610048 cites W2023809975 @default.
• W2009610048 cites W2024021696 @default.
• W2009610048 cites W2029372789 @default.
• W2009610048 cites W2037980227 @default.
• W2009610048 cites W2046230797 @default.
• W2009610048 cites W2053858732 @default.
• W2009610048 cites W2055994335 @default.
• W2009610048 cites W2076719655 @default.
• W2009610048 cites W2086313080 @default.
• W2009610048 cites W2097106158 @default.
• W2009610048 cites W2108336145 @default.
• W2009610048 cites W2127027932 @default.
• W2009610048 cites W2129971278 @default.
• W2009610048 cites W2140341667 @default.
• W2009610048 cites W2150368859 @default.
• W2009610048 cites W2427042909 @default.
• W2009610048 doi "https://doi.org/10.1172/jci119082" @default.
• W2009610048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507721" @default.
• W2009610048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8958226" @default.
• W2009610048 hasPublicationYear "1996" @default.
• W2009610048 type Work @default.
• W2009610048 sameAs 2009610048 @default.
• W2009610048 citedByCount "133" @default.
• W2009610048 countsByYear W20096100482012 @default.
• W2009610048 countsByYear W20096100482013 @default.
• W2009610048 countsByYear W20096100482014 @default.
• W2009610048 countsByYear W20096100482015 @default.
• W2009610048 countsByYear W20096100482017 @default.
• W2009610048 countsByYear W20096100482019 @default.
• W2009610048 countsByYear W20096100482020 @default.
• W2009610048 countsByYear W20096100482021 @default.
• W2009610048 countsByYear W20096100482023 @default.
• W2009610048 crossrefType "journal-article" @default.
• W2009610048 hasAuthorship W2009610048A5008050913 @default.
• W2009610048 hasAuthorship W2009610048A5009705533 @default.
• W2009610048 hasAuthorship W2009610048A5042097944 @default.
• W2009610048 hasAuthorship W2009610048A5053370481 @default.
• W2009610048 hasAuthorship W2009610048A5076073255 @default.
• W2009610048 hasAuthorship W2009610048A5077194201 @default.
• W2009610048 hasBestOaLocation W20096100481 @default.
• W2009610048 hasConcept C114684123 @default.
• W2009610048 hasConcept C134018914 @default.
• W2009610048 hasConcept C153911025 @default.
• W2009610048 hasConcept C154317977 @default.
• W2009610048 hasConcept C167672396 @default.
• W2009610048 hasConcept C190283241 @default.
• W2009610048 hasConcept C202751555 @default.
• W2009610048 hasConcept C203014093 @default.
• W2009610048 hasConcept C24998067 @default.
• W2009610048 hasConcept C2777310793 @default.
• W2009610048 hasConcept C529295009 @default.
• W2009610048 hasConcept C54355233 @default.
• W2009610048 hasConcept C55493867 @default.
• W2009610048 hasConcept C62478195 @default.
• W2009610048 hasConcept C86803240 @default.
• W2009610048 hasConcept C8891405 @default.
• W2009610048 hasConcept C95444343 @default.
• W2009610048 hasConceptScore W2009610048C114684123 @default.
• W2009610048 hasConceptScore W2009610048C134018914 @default.
• W2009610048 hasConceptScore W2009610048C153911025 @default.
• W2009610048 hasConceptScore W2009610048C154317977 @default.
• W2009610048 hasConceptScore W2009610048C167672396 @default.
• W2009610048 hasConceptScore W2009610048C190283241 @default.
• W2009610048 hasConceptScore W2009610048C202751555 @default.
• W2009610048 hasConceptScore W2009610048C203014093 @default.
• W2009610048 hasConceptScore W2009610048C24998067 @default.
• W2009610048 hasConceptScore W2009610048C2777310793 @default.
• W2009610048 hasConceptScore W2009610048C529295009 @default.
• W2009610048 hasConceptScore W2009610048C54355233 @default.
• W2009610048 hasConceptScore W2009610048C55493867 @default.

• next