Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009614918> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2009614918 endingPage "971" @default.
- W2009614918 startingPage "966" @default.
- W2009614918 abstract "IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci). A regulatory region recently identified downstream, the alpha1 gene of the IgH locus, was a likely candidate for the control of IgA1 production in patients. Alleles of this region, differing by size, sequence, and orientation of the alpha1 hs1,2 transcriptional enhancer, were first identified through Southern blot hybridization.We established a polymerase chain reaction (PCR) method suitable for routine testing that amplifies minisatellites within the alpha1 hs1, 2 enhancer, with variable numbers of tandem repeats (VNTR) defining the two alleles. This assay allowed the typing of 104 patients with IgAN and 83 healthy volunteers. Results from typing of alpha1 hs1,2 alleles were compared with long-term clinical outcome in patients. Enhancer alleles were compared in a luciferase reporter gene assay.The alpha1 hs1,2 alleles do not constitute a predictive factor for IgA nephropathy, since similar allelic frequencies were observed in healthy individuals and in unrelated European patients. In contrast, among patients, homozygosity for the weakest enhancer allele (AA genotype) was significantly correlated with a milder form of the disease, whereas the allele B was associated with severe evolution. The minisatellite region within the alpha1 hs1,2 enhancer carried potential transcription factor-binding sites, and its duplication increased the transcriptional strength of the alpha1 hs1, 2 allele B over that of allele A.Altogether, these alleles may constitute a risk factor for the prognosis of IgA nephropathy." @default.
- W2009614918 created "2016-06-24" @default.
- W2009614918 creator A5013842512 @default.
- W2009614918 creator A5030975056 @default.
- W2009614918 creator A5051446250 @default.
- W2009614918 creator A5061875124 @default.
- W2009614918 creator A5063030105 @default.
- W2009614918 creator A5063574799 @default.
- W2009614918 creator A5089880659 @default.
- W2009614918 date "2000-09-01" @default.
- W2009614918 modified "2023-09-25" @default.
- W2009614918 title "Alleles of the α1 immunoglobulin gene 3′ enhancer control evolution of IgA nephropathy toward renal failure" @default.
- W2009614918 cites W1612521420 @default.
- W2009614918 cites W1979091084 @default.
- W2009614918 cites W1981223276 @default.
- W2009614918 cites W2001314729 @default.
- W2009614918 cites W2014726017 @default.
- W2009614918 cites W2022167350 @default.
- W2009614918 cites W2024589789 @default.
- W2009614918 cites W2025470317 @default.
- W2009614918 cites W2026199642 @default.
- W2009614918 cites W2036018698 @default.
- W2009614918 cites W2036283668 @default.
- W2009614918 cites W2048965288 @default.
- W2009614918 cites W2050268469 @default.
- W2009614918 cites W2081381862 @default.
- W2009614918 cites W2083549635 @default.
- W2009614918 cites W2089688175 @default.
- W2009614918 cites W2135577623 @default.
- W2009614918 cites W2143014918 @default.
- W2009614918 cites W2156501795 @default.
- W2009614918 cites W2313025224 @default.
- W2009614918 cites W2315633440 @default.
- W2009614918 cites W3021948293 @default.
- W2009614918 cites W4313376360 @default.
- W2009614918 doi "https://doi.org/10.1046/j.1523-1755.2000.00253.x" @default.
- W2009614918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10972660" @default.
- W2009614918 hasPublicationYear "2000" @default.
- W2009614918 type Work @default.
- W2009614918 sameAs 2009614918 @default.
- W2009614918 citedByCount "49" @default.
- W2009614918 countsByYear W20096149182012 @default.
- W2009614918 countsByYear W20096149182013 @default.
- W2009614918 countsByYear W20096149182014 @default.
- W2009614918 countsByYear W20096149182015 @default.
- W2009614918 countsByYear W20096149182017 @default.
- W2009614918 countsByYear W20096149182018 @default.
- W2009614918 countsByYear W20096149182020 @default.
- W2009614918 countsByYear W20096149182023 @default.
- W2009614918 crossrefType "journal-article" @default.
- W2009614918 hasAuthorship W2009614918A5013842512 @default.
- W2009614918 hasAuthorship W2009614918A5030975056 @default.
- W2009614918 hasAuthorship W2009614918A5051446250 @default.
- W2009614918 hasAuthorship W2009614918A5061875124 @default.
- W2009614918 hasAuthorship W2009614918A5063030105 @default.
- W2009614918 hasAuthorship W2009614918A5063574799 @default.
- W2009614918 hasAuthorship W2009614918A5089880659 @default.
- W2009614918 hasBestOaLocation W20096149181 @default.
- W2009614918 hasConcept C104317684 @default.
- W2009614918 hasConcept C111936080 @default.
- W2009614918 hasConcept C153911025 @default.
- W2009614918 hasConcept C180754005 @default.
- W2009614918 hasConcept C54355233 @default.
- W2009614918 hasConcept C84597430 @default.
- W2009614918 hasConcept C86339819 @default.
- W2009614918 hasConcept C86803240 @default.
- W2009614918 hasConceptScore W2009614918C104317684 @default.
- W2009614918 hasConceptScore W2009614918C111936080 @default.
- W2009614918 hasConceptScore W2009614918C153911025 @default.
- W2009614918 hasConceptScore W2009614918C180754005 @default.
- W2009614918 hasConceptScore W2009614918C54355233 @default.
- W2009614918 hasConceptScore W2009614918C84597430 @default.
- W2009614918 hasConceptScore W2009614918C86339819 @default.
- W2009614918 hasConceptScore W2009614918C86803240 @default.
- W2009614918 hasIssue "3" @default.
- W2009614918 hasLocation W20096149181 @default.
- W2009614918 hasLocation W20096149182 @default.
- W2009614918 hasOpenAccess W2009614918 @default.
- W2009614918 hasPrimaryLocation W20096149181 @default.
- W2009614918 hasRelatedWork W1971410958 @default.
- W2009614918 hasRelatedWork W2002482473 @default.
- W2009614918 hasRelatedWork W2028087115 @default.
- W2009614918 hasRelatedWork W2057739827 @default.
- W2009614918 hasRelatedWork W2061630842 @default.
- W2009614918 hasRelatedWork W2130336506 @default.
- W2009614918 hasRelatedWork W2171895295 @default.
- W2009614918 hasRelatedWork W2176635671 @default.
- W2009614918 hasRelatedWork W2992461240 @default.
- W2009614918 hasRelatedWork W858891458 @default.
- W2009614918 hasVolume "58" @default.
- W2009614918 isParatext "false" @default.
- W2009614918 isRetracted "false" @default.
- W2009614918 magId "2009614918" @default.
- W2009614918 workType "article" @default.