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- W200962325 abstract "SUMMARY. A sensitive and specific method based on liquid chromatography was developed and validated for the determination of phenytoin in human plasma using phenobarbital as internal standard. The drugs were extracted from plasma by liquid-liquid extraction and separated isocratically on a Phenomenex Synergi MAX-RP C12 column (150 x 4.6 mm i.d.), with water: acetonitrile: methanol (58.8:15.2:26, v/v/v) as mobile phase. Detection was carried out using photodiode array detector set at 205 nm. The chromatographic separation was obtained within 12 min and was linear in the concentration range of 50-2500 ng/mL (r2 = 0.9999). The method was successfully applied for the bioequivalence study of two tablet formulations (test and reference) of phenytoin 100 mg after single oral dose administration to 28 healthy human volunteers. The 90% confidence intervals were calculated for the Cmax, AUC(0-t) and AUC(0-∞), giving values between 99.97–118.40% demonstrating the bioequivalence of the two formulations." @default.
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- W200962325 date "2009-01-01" @default.
- W200962325 modified "2023-09-26" @default.
- W200962325 title "Determination of Phenytoin in Human Plasma by a Validated Liquid Chromatography Method and its Application to a Bioequivalence Study" @default.
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