FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009623538> ?p ?o ?g. }

• W2009623538 abstract "Abstract It is widely believed that the proper activation of N-methyl-D-aspartate (NMDA) receptors (NMDARs) promotes neuronal survival, whereas an excessive activation of NMDARs leads to neuronal damage. NMDARs are found at both synaptic and extrasynaptic sites. One current prevailing theory proposes the dichotomy of NMDAR activity. The role of the two population receptors is mutual antagonism. The activation of synaptic NMDARs, such as synaptic activity at physiological levels, promotes neuronal survival. However, the activation of extrasynaptic NMDARs occurring during stroke, brain injury, and chronic neurological diseases contributes to neuronal death. Thus, the location of NMDARs determines the neuronal fate. However, the theory is greatly challenged. Several studies suggested that synaptic NMDARs are involved in neuronal death. Recently, our work further showed that the coactivation of synaptic and extrasynaptic NMDARs contributes to neuronal death under neuronal insults. Therefore, we propose that the magnitude and duration of NMDAR activation determines the neuronal fate. More interestingly, there appears to be some subtle differences in the affinity between synaptic and extrasynaptic NMDARs, shedding light on the development of selective drugs to block extrasynaptic NMDARs." @default.
• W2009623538 created "2016-06-24" @default.
• W2009623538 creator A5025985349 @default.
• W2009623538 creator A5054311605 @default.
• W2009623538 creator A5077699695 @default.
• W2009623538 creator A5081531782 @default.
• W2009623538 date "2015-01-01" @default.
• W2009623538 modified "2023-10-09" @default.
• W2009623538 title "NMDA receptor activity determines neuronal fate: location or number?" @default.
• W2009623538 cites W1485244052 @default.
• W2009623538 cites W1585306115 @default.
• W2009623538 cites W1639407471 @default.
• W2009623538 cites W1690684669 @default.
• W2009623538 cites W1858043581 @default.
• W2009623538 cites W1957958801 @default.
• W2009623538 cites W1966556202 @default.
• W2009623538 cites W1968024448 @default.
• W2009623538 cites W1971136633 @default.
• W2009623538 cites W1972462790 @default.
• W2009623538 cites W1977756329 @default.
• W2009623538 cites W1980059018 @default.
• W2009623538 cites W2002664835 @default.
• W2009623538 cites W2005816735 @default.
• W2009623538 cites W2006815009 @default.
• W2009623538 cites W2007387168 @default.
• W2009623538 cites W2008818812 @default.
• W2009623538 cites W2027275070 @default.
• W2009623538 cites W2030377743 @default.
• W2009623538 cites W2037921808 @default.
• W2009623538 cites W2041119702 @default.
• W2009623538 cites W2044514703 @default.
• W2009623538 cites W2044795903 @default.
• W2009623538 cites W2049611687 @default.
• W2009623538 cites W2058245542 @default.
• W2009623538 cites W2060944001 @default.
• W2009623538 cites W2063690295 @default.
• W2009623538 cites W2073508793 @default.
• W2009623538 cites W2075084014 @default.
• W2009623538 cites W2076357839 @default.
• W2009623538 cites W2080203024 @default.
• W2009623538 cites W2081070804 @default.
• W2009623538 cites W2081282178 @default.
• W2009623538 cites W2097095684 @default.
• W2009623538 cites W2104417933 @default.
• W2009623538 cites W2116635659 @default.
• W2009623538 cites W2121239869 @default.
• W2009623538 cites W2121737262 @default.
• W2009623538 cites W2147045345 @default.
• W2009623538 cites W2147917838 @default.
• W2009623538 cites W2162642602 @default.
• W2009623538 cites W2169207073 @default.
• W2009623538 cites W2171529265 @default.
• W2009623538 cites W2174668858 @default.
• W2009623538 doi "https://doi.org/10.1515/revneuro-2014-0053" @default.
• W2009623538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25324444" @default.
• W2009623538 hasPublicationYear "2015" @default.
• W2009623538 type Work @default.
• W2009623538 sameAs 2009623538 @default.
• W2009623538 citedByCount "11" @default.
• W2009623538 countsByYear W20096235382014 @default.
• W2009623538 countsByYear W20096235382015 @default.
• W2009623538 countsByYear W20096235382016 @default.
• W2009623538 countsByYear W20096235382018 @default.
• W2009623538 countsByYear W20096235382019 @default.
• W2009623538 countsByYear W20096235382022 @default.
• W2009623538 crossrefType "journal-article" @default.
• W2009623538 hasAuthorship W2009623538A5025985349 @default.
• W2009623538 hasAuthorship W2009623538A5054311605 @default.
• W2009623538 hasAuthorship W2009623538A5077699695 @default.
• W2009623538 hasAuthorship W2009623538A5081531782 @default.
• W2009623538 hasConcept C169760540 @default.
• W2009623538 hasConcept C170493617 @default.
• W2009623538 hasConcept C2908647359 @default.
• W2009623538 hasConcept C55493867 @default.
• W2009623538 hasConcept C67018056 @default.
• W2009623538 hasConcept C71924100 @default.
• W2009623538 hasConcept C74254510 @default.
• W2009623538 hasConcept C86803240 @default.
• W2009623538 hasConcept C99454951 @default.
• W2009623538 hasConceptScore W2009623538C169760540 @default.
• W2009623538 hasConceptScore W2009623538C170493617 @default.
• W2009623538 hasConceptScore W2009623538C2908647359 @default.
• W2009623538 hasConceptScore W2009623538C55493867 @default.
• W2009623538 hasConceptScore W2009623538C67018056 @default.
• W2009623538 hasConceptScore W2009623538C71924100 @default.
• W2009623538 hasConceptScore W2009623538C74254510 @default.
• W2009623538 hasConceptScore W2009623538C86803240 @default.
• W2009623538 hasConceptScore W2009623538C99454951 @default.
• W2009623538 hasIssue "1" @default.
• W2009623538 hasLocation W20096235381 @default.
• W2009623538 hasLocation W20096235382 @default.
• W2009623538 hasOpenAccess W2009623538 @default.
• W2009623538 hasPrimaryLocation W20096235381 @default.
• W2009623538 hasRelatedWork W2125297173 @default.
• W2009623538 hasRelatedWork W2139755184 @default.
• W2009623538 hasRelatedWork W2745891242 @default.
• W2009623538 hasRelatedWork W2820472930 @default.
• W2009623538 hasRelatedWork W3096957045 @default.
• W2009623538 hasRelatedWork W3135073914 @default.
• W2009623538 hasRelatedWork W3158782517 @default.

• next