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• W2009631415 abstract "H-2-linked immune response (Ir) genes specifically and distinctly control immunological responsiveness of mice to the non-cross-reacting enzyme antigens LDHA and LDHB. In a previous study (Melchers, I., Rajewsky, K. and Shreffler, D. C., Eur. J. Immunol. 1973. 3: 754) two levels of responsiveness to LDHB were found and mice could be classified into high and low responders (HR or LR). We now detect a third, intermediate level of responsiveness. In addition, in certain crosses, “superhigh” responses as well as responses in between the low and intermediate level are found. An apparently highly polymorphic system of Ir genes thus determines the level of responsiveness in a surprisingly discrete and precise way. In general, high or intermediate responsiveness was dominant over low responsiveness in F1 animals. In one out of four cases the cross between an intermediate responder (IMR) and a LR, which were congenic for H-2, resulted in a level of responsiveness in between that of the two parental strains. In crosses between IMR strains, the F1 animals were either again IMR or showed functional complementation to high responsiveness in two out of four combinations. The results can be explained in terms of two polymorphic loci which interact in the control of responsiveness to LDHB. Surprisingly, the B10.HTT strain, which carries the recombinant H-2t3 chromosome, is an IMR, although the H-2t3 chromosome carries the HR H-2s allele in the Ir-1B region, to which Ir-LDHB has been previously mapped. Complementation to high responsiveness is achieved when the H-2t3 chromosome is combined in an F1 cross with the H-2 chromosome from LR strains carrying “silent” HR alleles in the I-C and/or S regions (H-2a and H-2h2). This demonstrates that the response to LDHB is controlled by at least two separate, interacting loci within the H-2 complex. One of these loci maps, at least in the case of H-2s and H-2d, to the left of the I-C region, whereas the other is located in I-C or S, as again shown for the H-2d and H-2s haplotypes. One may speculate that these loci also mediate complementation between our IMR strains (see above) and exert distinct functions in the Ir gene control of the immune response." @default.
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• W2009631415 date "1975-11-01" @default.
• W2009631415 modified "2023-09-26" @default.
• W2009631415 title "Specific control of responsiveness by two complementing Ir loci in the H-2 complex" @default.
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• W2009631415 doi "https://doi.org/10.1002/eji.1830051105" @default.
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