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• W2009639295 startingPage "1109" @default.
• W2009639295 abstract "Mature rabbit spermatozoa from the cauda epididymidis suspended in potassium Tris phosphate buffer at 24°C produced O2⨪, as measured by reduction of acetylated ferricytochrome c, with an intrinsic rate of 0.20 nmol/min per 108 cells. This rate increased to 1.80 nmol/min per 108 cells in the presence of 10 mM cyanide. These spermatozoa contain 2.8 units per 108 cells of superoxide dismutase activity, 95% of which is sensitive, and 5% of which is insensitive, to cyanide inhibition. These activities correspond to the cytosolic Cu-Zn form and the mitochondrial Mn form of the dismutase, respectively. Only the cyanide-sensitive form is released from the sperm on hypo-osmotic treatment or sonication. Hypo-osmotically treated rabbit epididymal spermatozoa produced O2⨪ with an intrinsic rate of 0.24 nmol/min per 108 cells, which increased to 0.58 nmol/min per 108 cells in the presence of 10 mM cyanide. Both intact and hypo-osmotically treated cells react with O2⨪ in a second order reaction as inferred from the hyperbolic dependence on cell concentration of O2⨪ production rate in both the absence and presence of cyanide. The second order rate constant for this reaction with intact cells, kS, was calculated to be 22.9 × 10−8 (cells/ml)-1 min-1 in its absence. For hypo-osmotically treated cells, the values of kS were 10.8 × 10−8 (cells/ml)-1 min-1 and 8.2 × 10−8 (cells/ml) -1 min-1, respectively. Since hypo-osmotically treated cells have lost much of their plasma membrane, the lower value of kS for the treated cells implies that this membrane is one site of reaction of O2⨪ with the cells. The increase in kS in the presence of cyanide, which inhibits superoxide dismutase and so increases O2⨪ production, suggests that the cells become more reactive with O2⨪ as its production rate increase, as would be expected for the occurrence of radical chain oxidation. This in turn suggests that superoxide dismutase plays a major role in protecting rabbit sperm against damage from lipid peroxidation." @default.
• W2009639295 created "2016-06-24" @default.
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• W2009639295 date "1982-12-01" @default.
• W2009639295 modified "2023-09-27" @default.
• W2009639295 title "Production of Superoxide and Activity of Superoxide Dismutase in Rabbit Epididymal Spermatozoa" @default.
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• W2009639295 doi "https://doi.org/10.1095/biolreprod27.5.1109" @default.
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