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• W2009644403 endingPage "25" @default.
• W2009644403 startingPage "13" @default.
• W2009644403 abstract "Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally promotes CD8(+) T cell and natural killer cell cytolytic activity and modulates T cell differentiation programs in response to antigen, promoting naïve CD4(+) T cell differentiation into T helper 1 (Th1) and T helper 2 (Th2) cells while inhibiting T helper 17 (Th17) and T follicular helper (Tfh) cell differentiation. Moreover, IL-2 is essential for the development and maintenance of T regulatory cells and for activation-induced cell death, thereby mediating tolerance and limiting inappropriate immune reactions. In this review, we focus on the molecular mechanisms and complex cellular actions of IL-2, its cooperative and opposing effects with other cytokines, and how both promoting and blocking the actions of IL-2 are being utilized in clinical medicine." @default.
• W2009644403 created "2016-06-24" @default.
• W2009644403 creator A5012950291 @default.
• W2009644403 creator A5045690655 @default.
• W2009644403 creator A5049735724 @default.
• W2009644403 date "2013-01-01" @default.
• W2009644403 modified "2023-10-16" @default.
• W2009644403 title "Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy" @default.
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